Urinary transforming growth factor-beta 1 in membranous glomerulonephritis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
E HonkanenC Grönhagen-Riska

Abstract

Human idiopathic membranous glomerulonephritis (MGN) has a highly variable clinical course and factors determining its outcome are poorly known. Since transforming growth factor-beta 1 (TGF-beta 1) has an essential role in renal fibrogenesis, we studied the possibility to use urinary excretion of TGF-beta 1 in the assessment of progression of the disease in patients with MGN. Urinary TGF-beta 1 was determined in 41 patients with MGN, 25 healthy subjects, six non-proteinuric renal transplant patients, 10 patients with IgA glomerulonephritis, and seven proteinuric patients (with non-progressive diseases) using a novel, double antibody enzyme immunoassay. The results were compared with renal morphology and clinical indices of activity of MGN over 12 months. The median urinary TGF-beta 1 excretion (pg/mg creatinine) was significantly higher (1730; range 60-16,970) in MGN patients than in the healthy controls (300; 30-1330; P < 0.0001). In renal allograft recipients the excretion was 840 (250-3440; P < 0.0001 vs healthy controls), in IgA GN it was 1130 (30-4910; P = 0.039), and in proteinuric patients it was 39 (29-165; P = NS). In MGN but not in the proteinuric controls or renal allograft recipients, urinary TGF-beta 1 correlated w...Continue Reading

Citations

Aug 19, 2007·World Journal of Urology·Stephane DecramerJoost P Schanstra
Oct 19, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anna M Wasilewska, Walentyna M Zoch-Zwierz
Feb 17, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·María Gracia CalettiAdriana Haydeé Roy
Jan 22, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rebecca Wing-Yan Chan, Cheuk-Chun Szeto
Jan 17, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pierina De MuroGian Mario Cherchi
Dec 28, 1999·Microbes and Infection·M H Branton, J B Kopp
Mar 17, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·E KorpinenO Vaarala
May 16, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hyeong Cheon ParkDae Suk Han
Dec 9, 2004·Current Opinion in Nephrology and Hypertension·Raimund Hirschberg, Shinong Wang
May 11, 2005·Kidney International·Marion HaubitzHarald Mischak
Sep 17, 2005·Kidney International·Edith RogierMarie-Françoise Bourgeade
May 9, 2006·American Journal of Nephrology·Sotiris Tsakas, Dimitrios S Goumenos
May 19, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Jan A J G van den BrandJack F M Wetzels
Dec 14, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Jan A J G van den BrandJack F M Wetzels
Jun 20, 2002·Medicinski pregled·Dejan PetrovićBiljana Stojimirović
May 27, 2009·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Ahmed A Shokeir
Jun 21, 2014·Advanced Biomedical Research·Alireza Merrikhi, Emad Bahraminia
Jun 4, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dima HamidehOfelia Alvarez
Jul 9, 2016·The Veterinary Journal·J S LawsonJ Elliott
Jun 24, 2011·Kidney International·Robert G FassettWendy E Hoy
Jun 15, 2016·Biosensors & Bioelectronics·E Sánchez-TiradoJ M Pingarrón
Nov 29, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Peggy W G du Buf-VereijkenJack F M Wetzels
Mar 8, 2016·Journal of Biomolecular Screening·Giorgio Gentile, Giuseppe Remuzzi
Mar 8, 2014·Advances in Chronic Kidney Disease·Yasar Caliskan, Krzysztof Kiryluk
Jan 12, 1999·Lupus·D T Boumpas, J E Balow
Jan 7, 2006·The Journal of Veterinary Medical Science·Sayaka ArataHajime Tsujimoto
Aug 31, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hermine I BrunnerPrasad Devarajan
Sep 18, 2020·Journal of Indian Association of Pediatric Surgeons·Pranay PanigrahiShiv Prasad Sharma
Dec 18, 2002·Experimental Biology and Medicine·Jingfei Cheng, Joseph P Grande
Jul 30, 2019·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Ahlam BadawyAlmontaser Hussein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.