Urinary transforming growth factor-beta (TGF-beta) excretion and renal production of TGF-beta in rats with subtotal renal ablation: effect of enalapril and nifedipine

Nephron
A S Monteiro de FreitasE A Baroni

Abstract

The aim of the present study was to investigate the effect of enalapril and nifedipine on renal transforming growth factor-beta (TGF-beta) production and on the rate of urinary TGF-beta excretion in rats with subtotal renal ablation. After subtotal nephrectomy some animals were treated with enalapril or nifedipine. Renal cortical TGF-beta mRNA levels were 68% higher in untreated nephrectomized rats (p < 0.05) and 39% higher in rats treated with nifedipine (p < 0.05) compared with controls. There was no difference in renal cortical TGF-beta mRNA content between the nephrectomized rats treated with enalapril and sham animals, showing that enalapril treatment prevented the increase of TGF-beta mRNA in nephrectomized rats. The rate of urinary TGF-beta excretion was 2.2 +/- 0.8 pg/min in sham animals, 61.5 +/- 40.1 pg/min in untreated nephrectomized rats, 9.6 +/- 4.2 pg/min in nephrectomized rats treated with enalapril, and 55.2 +/- 24.46 pg/min in rats treated with nifedipine. The immunohistochemical reaction for TGF-beta in the renal cortex was less intense in the nephrectomized rats treated with enalapril than in the other groups of rats with subtotal renal ablation. These data show that enalapril induces a decrease in renal TGF-...Continue Reading

Citations

Feb 20, 2003·Diabetes/metabolism Research and Reviews·Rildo Aparecido VolpiniTerezila Machado Coimbra
Oct 19, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anna M Wasilewska, Walentyna M Zoch-Zwierz
May 16, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hyeong Cheon ParkDae Suk Han
Aug 30, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Masaharu MasudaMasatake Fukunami
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·T J SoaresJ Antunes-Rodrigues
Mar 13, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hyeong Cheon ParkDae Suk Han
Oct 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G T ShinD Kim
Jul 9, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Claudia do C MaquiaveliTerezila M Coimbra
Jul 27, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T J GeleileteT M Coimbra

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