PMID: 8602003Mar 16, 1996Paper

Urinary trypsinogen-2 test strip for acute pancreatitis

Lancet
J HedströmU Stenman

Abstract

A simple, rapid test is specific and sensitive enough to distinguish, in patients with clinically suspected acute pancreatitis, those whose abdominal pain is indeed of pancreatic origin has proved elusive. In two consecutive series of surgical patients in a teaching hospital, whose acute abdominal pain turned out to be due to acute pancreatitis (n-57) or extrapancreatic in origin (n=40), we studied urinary trypsinogen-2 in two ways. A test strip, incorporating monoclonal antibodies to two epitopes on trypsinogen-2, recorded a blue line when concentrations exceeded 50 microgram/L; we also measured trypsinogen-2 concentrations in the laboratory. In the patients with acute pancreatitis the test strip was positive in 52 and negative in five, whereas in the 40 extrapancreatic controls there were four false positives. In a further set of 57 orthopaedic controls, one urine was strip-test positive. Concentrations of urinary trypsinogen-2 and the test-strip results were in good agreement and in only three of the 154 patients were the two approaches discrepant, at the 50 microgram/L cut-off. These findings, in patients whose acute abdominal pain was known to be pancreatic in origin or not, are encouraging but need to be confirmed in a co...Continue Reading

References

May 17, 1986·Lancet·I R GunnM G Clayton
Feb 14, 1985·The New England Journal of Medicine·A D MayerC W Imrie
Dec 1, 1989·The British Journal of Surgery·P A ClavienA R Moossa
Jul 1, 1985·Gut·A P CorfieldR C Williamson
Dec 1, 1984·The British Journal of Surgery·P J HoldsworthM J McMahon

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Citations

Jul 10, 2003·The Journal of Surgical Research·Marko LempinenEsko Kemppainen
Jun 8, 2002·Veterinary Immunology and Immunopathology·Takaki WaritaniTakatsugu Yamada
May 10, 2002·Journal of Gastroenterology and Hepatology·J ToouliUNKNOWN Working Party of the Program Commitee of the Bangkok World Congress of Gastroenterology 2002
Jun 19, 1997·The New England Journal of Medicine·E A KemppainenU H Stenman
Jun 22, 2001·Journal of Clinical Gastroenterology·M ChwistekY Amoateng-Adjepong
Sep 16, 2009·Pancreas·Anders Møller AndersenMark Berner Hansen
Apr 7, 2012·Pancreas·Toshihiko MayumiUNKNOWN Urinary Trypsinogen-2 Dipstick for Acute Pancreatitis Study Group of Japanese Society of Abdominal Emergency Medicine (UtrAP
May 16, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Jens WernerMarkus W Büchler
May 16, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Christophe A MüllerAnders Borgström
Aug 20, 2015·Critical Reviews in Clinical Laboratory Sciences·Ulf-Håkan Stenman
Mar 7, 2006·Critical Reviews in Clinical Laboratory Sciences·Annukka Paju, Ulf-Håkan Stenman
Feb 19, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Outi Itkonen
Aug 9, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Tao JinQing Xia
Sep 20, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Timothy H RainerDennis Y M Lo
Jan 7, 2009·The British Journal of Surgery·R MofidiR W Parks
Sep 9, 2015·Journal of Biomarkers·Susanta MeherManoj Kumar Sahu
Mar 6, 2002·Journal of Feline Medicine and Surgery·C S Mansfield, B R Jones
Dec 22, 1999·The British Journal of Surgery·M Kylänpää-BäckU Stenman
May 15, 2002·Addiction Biology·Marja-Leena Kylänpää-BäckEsko Kemppainen
Apr 11, 2001·European Journal of Gastroenterology & Hepatology·R PezzilliB Barakat
Apr 22, 2017·The Cochrane Database of Systematic Reviews·Gianluca RompianesiKurinchi Selvan Gurusamy
Oct 22, 2009·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Ji Kon Ryu
Jul 17, 1998·Annals of Medicine·E A KemppainenU H Stenman
Sep 17, 2011·Clinical Chemistry·Jani OivaHannu Koistinen
Jan 16, 2019·World Journal of Gastroenterology : WJG·Hiroaki YasudaTooru Shimosegawa
Sep 15, 2020·Journal of Clinical Gastroenterology·Mia RainioLeena Kylänpää
Aug 24, 1999·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·U PeterssonA Borgström
Aug 29, 2013·Analytical Chemistry·Eleonora Petryayeva, W Russ Algar

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