Urinary versus plasma neutrophil gelatinase-associated lipocalin (NGAL) as a predictor of mortality for acute kidney injury in intensive care unit patients

Journal of Clinical Anesthesia
Ata MahmoodpoorNader D Nader

Abstract

To examine urinary and plasma neutrophil gelatinase-associated lipocalin (NGAL) levels in predicting ICU mortality. Prospective observational. University Critical Care setting. 50 patients with acute kidney injury (AKI). None. Serial urinary and plasma concentrations of NGAL were measured. Twenty-five patients had early progression (EP) and 25 patients had early improvement (EI) of AKI. Plasma concentrations of NGAL in the EP group (N=25) were significantly higher than those in the EI group (129 [IQR; 20] vs. 111 [IQR; 32] ng/mL; P=0.009), while urine NGAL levels on admission were similar in both groups (61 [IQR; 20] vs. 65 [IQR; 20] ng/mL; P=0.767). Plasma NGAL concentrations rapidly decreased to 87 [32] ng/mL in the EI group (P<0.001) and while it remained elevated in the EP group (138 [21] ng/mL). Within 28-days, 50% of the patients died in the EP group, whereas no patient died in the EI group (P<0.001). Plasma NGAL was a fair predictor for progression of AKI (AUC; 0.719±0.063; P=0.006). 48-hour changes in plasma NGAL levels predicted death within 28-days of ICU admission (AUC; 0.874±0.048; P<0.001). Early progression of AKI was associated with more death within 28 and 90days. While one time measurement of plasma NGAL levels...Continue Reading

References

Jan 19, 2007·Journal of the American Society of Nephrology : JASN·Kai M Schmidt-OttJonathan Barasch
Apr 28, 2007·Contributions to Nephrology·John A KellumClaudio Ronco
Aug 7, 2007·Critical Care : the Official Journal of the Critical Care Forum·Michael ZappitelliStuart L Goldstein
Dec 6, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Konstantinos MakrisAlexander Haliassos
Oct 24, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael HaaseUNKNOWN NGAL Meta-analysis Investigator Group
May 28, 2011·Journal of the American College of Cardiology·Kevin DammanDirk J van Veldhuisen
Mar 16, 2012·Kidney International·Maryam NejatZoltán H Endre
May 18, 2013·Critical Care : the Official Journal of the Critical Care Forum·Peter B HjortrupAnders Perner
Jul 6, 2014·Critical Care : the Official Journal of the Critical Care Forum·Ramprasad MatsaLiza Keating
Mar 1, 2012·Kidney International Supplements
Jan 22, 2015·Revista Brasileira de terapia intensiva·Mirian WatanabeMaria de Fatima Fernandes Vattimo
Apr 30, 2015·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Luis Alberto Batista PeresTiemi Matsuo
Jun 22, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Fangfang ZhouLina Han
May 6, 2016·Journal of Intensive Care Medicine·Niranjan JeganathanRobert A Balk
Jul 15, 2016·Revista Do Instituto De Medicina Tropical De São Paulo·Leonardo Duarte Sobreira LunaElizabeth De Francesco Daher

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Citations

Jul 1, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Stan J F HartmanSaskia N de Wildt
Jan 11, 2020·Critical Care : the Official Journal of the Critical Care Forum·Esther Nkuipou-KenfackUNKNOWN French and European Outcome Registry in Intensive Care Unit Investigators
Feb 20, 2021·PloS One·Marcos Antonio Marton FilhoNorma Sueli Pinheiro Módolo

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