Urinary Vitamin D-Binding Protein as a Biomarker of Steroid-Resistant Nephrotic Syndrome

Biomarker Insights
Michael R BennettPrasad Devarajan

Abstract

Idiopathic nephrotic syndrome (NS) is one of the most common glomerular disorders of childhood and is associated with increased urinary vitamin D-binding protein (uVDBP) excretion. We tested the hypothesis that uVDBP represents a biomarker to differentiate steroid-resistant nephrotic syndrome (SRNS) from the more benign forms of steroid-sensitive nephrotic syndrome (SSNS). This cross-sectional study included children with SRNS (n = 24), SSNS (n = 28), and normal controls (n = 5). Urine and clinical data were collected from patients. Measurements of uVDBP were performed with a commercially available ELISA kit and normalized to urine creatinine. Concentrations of uVDBP were significantly higher (P < 0.001) in patients with SRNS (13,659 ng/mL, interquartile range [IQR] 477-22,979) than in patients with SSNS (94 ng/mL, IQR 53-202) and normal controls (23 ng/mL, IQR 22-99, P = 0.002). Significance did not change when the results were corrected for urine creatinine. uVDBP was significantly negatively correlated with estimated glomerular filtration rate (eGFR; R = -0.76, P = 0.03). However, uVDBP was still markedly elevated in patients with SRNS with eGFR >100 mL/minute/1.73 m(2). There was a positive correlation between microalbuminu...Continue Reading

References

Sep 24, 1977·Lancet·J M BarragryR D Cohen
Jun 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A GrymonprezR Bouillon
Jul 21, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D C Cattran, P Rao
Apr 1, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T SrivastavaU S Alon
May 7, 1999·Kidney International·M Bonilla-FelixR Verani
Jun 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S M Korbet
Oct 12, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S GulatiA Gupta
Jan 10, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·P VallésW Manucha
Oct 31, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·P HariR N Srivastava
Jul 11, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sanjeev GulatiR K Gupta
Aug 29, 2003·Lancet·Allison A Eddy, Jordan M Symons
Dec 17, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Francis L WengMary B Leonard
Jan 6, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Debbie S GipsonDavid B Thomas
Jun 10, 2006·American Journal of Nephrology·Robert P WoronieckiEdmond O'Riordan
Oct 5, 2007·American Journal of Nephrology·Robert P WoronieckiFrederick J Kaskel
Jan 23, 2009·Journal of the American Society of Nephrology : JASN·George J SchwartzSusan L Furth
Mar 11, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Isabel Roberti, Shefali Vyas
Oct 1, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Carolina R C DoorenbosMartin H de Borst
Dec 28, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael R BennettPrasad Devarajan
May 29, 2014·International Journal of Endocrinology·Pegah YousefzadehXiangbing Wang

❮ Previous
Next ❯

Citations

Jan 18, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Navinder K JassilXiangbing Wang
May 5, 2017·Biomarker Insights·Michael R BennettPrasad Devarajan
Sep 30, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Xiangbing WangHaidar Al-Hraishawi
Oct 28, 2019·Nature Reviews. Nephrology·Moin A Saleem
Jul 21, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sushmita BanerjeeJayati Sengupta
Jan 4, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gabriel Cara-Fuentes, William E Smoyer
Mar 7, 2021·Medicina·Guido GembilloDomenico Santoro
Aug 28, 2021·British Journal of Clinical Pharmacology·Mandy WanJignesh P Patel

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
ELISA

Software Mentioned

Sigmaplot

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Rong-yan ChenYue-qiang Wen
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Ai-Wen HuangZhu-Wen Yi
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
You-Lin TainKuender D Yang
© 2022 Meta ULC. All rights reserved