Urine Aquaporin-2: A Promising Marker of Response to the Arginine Vasopressin Type-2 Antagonist, Tolvaptan in Patients with Congestive Heart Failure

International Journal of Molecular Sciences
Teruhiko Imamura, Koichiro Kinugawa

Abstract

Aquaporin-2, a member of the aquaporin family, is an arginine vasopressin-regulated water channel expressed in the renal collecting duct, and a promising marker of the concentrating and diluting ability of the kidney. The arginine vasopressin type-2 antagonist, tolvaptan, is a new-generation diuretic; it is especially indicated in patients with decompensated heart failure refractory to conventional diuretics. However, the ideal responders to tolvaptan have not yet been identified, and non-responders experience worse clinical courses despite treatment with tolvaptan. Urine aquaporin-2 has recently been demonstrated as a promising predictor of response to tolvaptan. We here validated aquaporin-2-guided tolvaptan therapy in patients with decompensated heart failure. Long-term efficacy of tolvaptan treatment in the responders defined by aquaporin-2 needs to be validated in the future prospective study.

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Citations

May 26, 2017·International Heart Journal·Keisuke Kida
Jul 2, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hideto KawarataniHitoshi Yoshiji
Feb 1, 2020·The Journal of International Medical Research·Shao OuyangChangcheng Lei
Aug 12, 2020·CEN Case Reports·Kota KakeshitaKoichiro Kinugawa
Nov 5, 2019·American Journal of Physiology. Renal Physiology·Wen SuYoufei Guan
Feb 10, 2021·Journal of Cellular Physiology·Moein AlaAhmad Reza Dehpour

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