Urine as a biological modality for colorectal cancer detection.

Expert Review of Molecular Diagnostics
Subashini Chandrapalan, R Arasaradnam

Abstract

Introduction: The increasing incidence of colorectal cancer (CRC) in young adults warrants early and preferably noninvasive diagnostic modalities. Although the current stool-based assays have had good performance indicators for CRC detection, the overall poor uptake remains a challenging issue. However, alternative blood and urine markers are emerging.Areas covered: This paper discusses the various urinary biomarkers available for the detection of CRC. The more commonly encountered drawbacks are the small number of studies and the size of the study population. We discuss the role of microRNA and ProstaglandinE2 in CRC detection. The emergence of new, low-cost technologies, specifically in the detection of volatile organic compounds (VOCs), presents a promising future. We postulate possible mechanisms for the origin of these VOCs in urine and their role in carcinogenesis.Expert opinion: Urinary biomarkers provide an alternative option to the stool-based screening tests. MicroRNA and ProstaglandinE2 have shown utility in CRC detection. Evidence so far suggests that VOCs could also be a potential biomarker for the detection of CRC. In addition to its interaction within the colon lumen, this altered 'VOC signature' might also play ...Continue Reading

References

Mar 1, 1990·Risk Analysis : an Official Publication of the Society for Risk Analysis·J A Stolwijk
Oct 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·L PaulingP Cary
Jan 21, 1993·International Journal of Cancer. Journal International Du Cancer·F ItohA Yachi
Oct 3, 1999·Cancer Metastasis Reviews·P AnkerM Stroun
May 20, 2000·Annals of the New York Academy of Sciences·H E MulcahyM Stroun
Sep 17, 2004·Nature·Victor Ambros
Feb 17, 2005·Pancreas·Beata SchlichtholzJulian Swierczynski
Jan 20, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G M MackayL G Darlington
Sep 26, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·J Chad JohnsonNipun B Merchant
Oct 3, 2006·The International Journal of Biological Markers·B MelicharZ Zadák
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Qiuyin CaiWei Zheng
Apr 14, 2007·Biomedical Chromatography : BMC·Bogusław BuszewskiAnton Amann
Dec 10, 2008·Arhiv za higijenu rada i toksikologiju·Sibel BayilMuhsin Hazar
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
May 29, 2009·Medical Hypotheses·R P ArasaradnamS Kumar
Feb 4, 2010·Journal of Proteome Research·Yunping QiuWei Jia
Jan 6, 2011·Journal of Medical Engineering & Technology·R P ArasaradnamJ A Covington
May 7, 2011·International Journal of Cancer. Journal International Du Cancer·Aviram NissanAli Osmay Gure
May 28, 2011·Scandinavian Journal of Gastroenterology·Katarzyna WalczakWaldemar A Turski
Jun 16, 2011·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Karen M KuntzAnn G Zauber
Jan 19, 2012·The Journal of Molecular Diagnostics : JMD·Benjamin P SongYing-Hsiu Su
Sep 11, 2012·International Journal of Oncology·Seok Joong YunWun-Jae Kim
Dec 12, 2012·Cancer Causes & Control : CCC·Valentina RosatoCarlo La Vecchia
Jan 18, 2013·BMC Genomics·Paul F BrayIsidore Rigoutsos
May 15, 2013·BMC Genomics·Xiaoyi HuangLiang Wang
May 25, 2013·Journal of the National Cancer Institute·Yuji ToiyamaAjay Goel
Oct 1, 2014·PloS One·Ramesh P ArasaradnamJames A Covington
Dec 4, 2014·Biosensors & Bioelectronics·E WestenbrinkJ A Covington
Feb 26, 2015·Journal of the National Cancer Institute·Krasimira AleksandrovaPaolo Vineis
Jul 17, 2015·JAMA Oncology·UNKNOWN Global Burden of Disease Cancer CollaborationMohsen Naghavi
Sep 1, 2015·Journal of Biomarkers·Kamila Schmidt, Ian Podmore
Jan 21, 2017·BMC Genomics·Anastasiya Vladimirovna SnezhkinaAnna Viktorovna Kudryavtseva
May 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Maria Luisa GasparriPierluigi Benedetti Panici
Sep 17, 2017·Oncotarget·Hsiao-Wei KaoWen-Chang Lin
Jan 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katalin SasLászló Vécsei

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