Urine-associated horizontal transmission of Seoul virus among rats

Archives of Virology
Hiroaki KariwaN Hashimoto

Abstract

To understand the mode of transmission of Seoul type hantavirus in Wistar rats, we examined the shedding of the virus and antibody production in infected rats. When 1-day-old rats were inoculated with KI-83-262 strain of Seoul virus, the S segment of the viral genome was detected in lungs, clots, urine, saliva, submaxillary glands, rectums, and kidneys by nested reverse transcriptase PCR. On the other hand, when 8-week-old rats were infected with the virus, viral genome was detected only in the lungs and rectum. In uninfected newborn rats intranasally administered urine from infected newborn rats, four of six rats shed the virus into their urine. In addition, three of eight rats kept in same cage with infected animals also shed the virus into urine. Moreover, the virus genome was detected in the urine of urban rats (Rattus norvegicus) in an enzootic focus. These findings suggest that the urine containing virus from infected rats is an actual source of Seoul virus infection.

Citations

Mar 13, 2009·Journal of Virology·Paula GodoyMarcelo López-Lastra
Dec 2, 2008·PLoS Pathogens·Judith D Easterbrook, Sabra L Klein
May 3, 2014·Viruses·Renata Carvalho de OliveiraElba Regina Sampaio de Lemos
Sep 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Judith D EasterbrookSabra L Klein
Oct 8, 2008·Immunological Reviews·Günther SchönrichRainer G Ulrich
Jun 12, 2010·Annals of the New York Academy of Sciences·M Denise Dearing, Laurie Dizney
Jun 3, 2020·The Journal of Infectious Diseases·Barbara KnustUNKNOWN Multistate Seoul Virus Outbreak Investigation Team
Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Michael Hilary D'Souza, Trushar R Patel
Sep 10, 2020·Frontiers in Cellular and Infection Microbiology·Danny NoackBarry H G Rockx

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