Urine biomarkers of chronic kidney damage and renal functional decline in childhood-onset systemic lupus erythematosus.

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Hermine I BrunnerPrasad Devarajan

Abstract

To delineate urine biomarkers that reflect kidney structural damage and predict renal functional decline in pediatric lupus nephritis (LN). In this prospective study, we evaluated kidney biopsies and urine samples of 89 patients with pediatric LN. Urinary levels of 10 biomarkers [adiponectin, ceruloplasmin, kidney injury molecule-1, monocyte chemotactic protein-1, neutrophil gelatinase-associated lipocalin, osteopontin, transforming growth factor-ß (TGFß), vitamin-D binding protein, liver fatty acid binding protein (LFABP), and transferrin] were measured. Regression analysis was used to identify individual and combinations of biomarkers that determine LN damage status [NIH-chronicity index (NIH-CI) score ≤ 1 vs. ≥ 2] both individually and in combination, and biomarker levels were compared for patients with vs. without renal functional decline, i.e., a 20% reduction of the glomerular filtration rate (GFR) within 12 months of a kidney biopsy. Adiponectin, LFABP, and osteopontin levels differed significantly with select histological damage features considered in the NIH-CI. The GFR was associated with NIH-CI scores [Pearson correlation coefficient (r) = - 0.49; p < 0.0001] but not proteinuria (r = 0.20; p > 0.05). Similar to the G...Continue Reading

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Citations

Aug 8, 2019·Current Opinion in Rheumatology·Anne DavidsonMeggan Mackay
Oct 6, 2020·Frontiers in Medicine·Lindsey R TheutErika I Boesen
Dec 20, 2019·Nature Reviews. Nephrology·Deepak A RaoBetty Diamond
Mar 24, 2020·Nature Reviews. Rheumatology·Naomi I Maria, Anne Davidson
Dec 16, 2020·International Journal of Molecular Sciences·Jarosław PrzybycińskiAndrzej Pawlik
Mar 8, 2021·BMC Nephrology·Colleen S Curran, Jeffrey B Kopp
Jul 11, 2021·Paediatric Drugs·Vitor Cavalcanti TrindadeClovis Artur Silva

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