Urine biopsy technologies: Cancer and beyond.

Theranostics
Chun Kwan ChenBee Luan Khoo

Abstract

Since the discovery of circulating tumor cells in 1869, technological advances in the study of biomarkers from liquid biopsy have made it possible to diagnose disease in a less invasive way. Although blood-based liquid biopsy has been used extensively for the detection of solid tumors and immune diseases, the potential of urine-based liquid biopsy has not been fully explored. Advancements in technologies for the harvesting and analysis of biomarkers are providing new opportunities for the characterization of other disease types. Liquid biopsy markers such as exfoliated bladder cancer cells, cell-free DNA (cfDNA), and exosomes have the potential to change the nature of disease management and care, as they allow a cost-effective and convenient mode of patient monitoring throughout treatment. In this review, we addressed the advancement of research in the field of disease detection for the key liquid biopsy markers such as cancer cells, cfDNA, and exosomes, with an emphasis on urine-based liquid biopsy. First, we highlighted key technologies that were widely available and used extensively for clinical urine sample analysis. Next, we presented recent technological developments in cell and genetic research, with implications for the...Continue Reading

Citations

May 1, 2021·Biomolecules·Elizabeth Martínez-RojoJesica Escobar-Cabrera
Jun 3, 2021·Cancers·Masanori OshiKazuaki Takabe
Jun 22, 2021·Biosensors & Bioelectronics·Junchen LiaoBee Luan Khoo

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Methods Mentioned

BETA
biopsy
biopsies
PCR
flow cytometry
RNA-seq
CAPP-Seq
ELISA
affinity binding
chips
chip

Software Mentioned

SP
FatSeqS
BinaxNOW
UroSeqS
GenomeSequencer
UroSEEKs
TERTSeqS
UroSEEK

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