Urine concentrations of apolipoprotein AI in renal tubular proteinuria

Metabolism: Clinical and Experimental
D Reichl, R Beetham

Abstract

To test the hypothesis that a significant proportion of apolipoprotein AI (apoAI) metabolism occurs through glomerular filtration of free apoAI in serum and subsequent renal tubular metabolism, we have examined the urine concentration of apoAI in three situations in which proximal tubular reabsorption of another protein metabolized in this manner and retinol-binding protein (RBP) was impaired. Following infusion of a cross-linked gelatin polymer (Haemaccel) in four normal subjects, urine RBP excretion (normally about 100 micrograms/L), was between 14 and 46 mg/L, while urine apoAI excretion was less than 0.5 mg/L. On the third day following cardiac surgery involving Haemaccel infusion, urine RBP was between 27 and 159 mg/L while urine apoAI excretion was again less than 0.5 mg/L. In 16 samples from eight patients recently transplanted with allograft kidneys, urine RBP was between 9 and 70 mg/L, whereas in only two samples was apoAI detected in the urine at 0.5 mg/L. These results have been taken to indicate that significant metabolism of apoAI through glomerular filtration and tubular absorption is unlikely to occur in humans.

References

Feb 14, 1978·Biochemical and Biophysical Research Communications·H B BrewerT J Bronzert
Dec 28, 1978·The New England Journal of Medicine·R M GlickmanA Tall
Aug 18, 1983·The New England Journal of Medicine·J J MaciejkoS J Mao
Mar 12, 1982·Biochimica Et Biophysica Acta·D Reichl, J J Pflug

Citations

Jun 8, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·P G KornetiB K Korneti

Related Concepts

Apolipoproteins A
Renal Tubule Structure
Proteinuria
Retinoid Binding Protein, F-Type
Pro-Apolipoprotein A-I

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