Urine-derived cells for human cell therapy

Stem Cell Research & Therapy
Nimshitha Pavathuparambil Abdul ManaphXin-Fu Zhou

Abstract

Desirable cells for human cell therapy would be ones that can be generated by simple isolation and culture techniques using a donor sample obtained by non-invasive methods. To date, the different donor-specific cells that can be isolated from blood, skin, and hair require invasive methods for sample isolation and incorporate complex and costly reagents to culture. These cells also take considerable time for their in-vitro isolation and expansion. Previous studies suggest that donor-derived cells, namely urine stem cells and renal cells, may be isolated from human urine samples using a cost-effective and simple method of isolation, incorporating not such complex reagents. Moreover, the isolated cells, particularly urine stem cells, are superior to conventional stem cell sources in terms of favourable gene profile and inherent multipotent potential. Transdifferentiation or differentiation of human urine-derived cells can generate desirable cells for regenerative therapy. In this review, we intended to discuss the characteristics and therapeutic applications of urine-derived cells for human cell therapy. Conclusively, with detailed study and optimisation, urine-derived cells have a prospective future to generate functional lineage...Continue Reading

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Citations

May 11, 2019·Journal of Clinical Medicine·Maria Sofia Falzarano, Alessandra Ferlini
Sep 25, 2019·Stem Cell Research & Therapy·Nimshitha Pavathuparambil Abdul ManaphChristopher John Drogemuller
Mar 19, 2020·Molecular Biology Reports·Donghui LiuXin-Fu Zhou
Dec 6, 2018·Journal of Cellular Physiology·Alireza HassanshahiCory J Xian
Aug 24, 2018·Stem Cell Research & Therapy·Nimshitha Pavathuparambil Abdul ManaphXin-Fu Zhou
Jan 11, 2020·Frontiers in Molecular Neuroscience·Mitsuto SatoYoshitsugu Aoki
Mar 20, 2020·Physiological Reviews·Marianela G DalghiGerard Apodaca
Jan 21, 2021·International Journal of Molecular Sciences·Asmaa A ZidanPlinio R Hurtado
Nov 13, 2020·World Journal of Stem Cells·Perrine BurdeyronClara Steichen
Jul 3, 2021·Cells·Tjessa BondueMohamed A Elmonem
Feb 19, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Fareeha Faizan Ghori, Mohsin Wahid

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Methods Mentioned

BETA
scraping
biopsy

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