PMID: 26321027Sep 1, 2015Paper

Urine fibroblast growth factor 23 levels in hypertensive children and adolescents

Croatian Medical Journal
Magdalena ZającAnna Wasilewska

Abstract

To determine the correlation of urinary fibroblast growth factor 23 (FGF23) excretion with blood pressure and calcium-phosphorus metabolism. The study included 42 hypertensive (17 girls) and 46 healthy children and adolescents (17 girls) aged 6-18 years admitted to the Department of Pediatrics and Nephrology, Medical University of Białystok between January 2013 and December 2013. FGF23 in urine was measured using Human Intact FGF-23 ELISA Kit. Hypertensive participants had significantly higher urine FGF23/creatinine values than the reference group (8.65 vs 5.59 RU/mg creatinine, P=0.007). Urine FGF23/creatinine positively correlated with systolic blood pressure in all participants. In hypertensive patients, urine FGF23/creatinine positively correlated with serum calcium and negatively with serum 25(OH)D, urinary calcium, phosphorus, and magnesium. This study found that FGF23 may play an important role in the pathogenesis of hypertension in children and adolescents, but our results should be confirmed by further studies.

Citations

May 1, 2019·Current Hypertension Reviews·Katerina ChrysaidouStella Stabouli
May 7, 2019·Frontiers in Pediatrics·Yao LinMingming Zhang
Oct 26, 2016·Current Opinion in Endocrinology, Diabetes, and Obesity·Jasveen BatraMichal L Melamed
Nov 26, 2020·International Journal of Molecular Sciences·Maria L MaceEwa Lewin

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