PMID: 40327Mar 1, 1979

Urine gamma-glutamyl transferase in rat kidney toxicology: nephropathy by repeated injections of mercuric chloride. Effects of sodium selenite

Toxicology
S SenerV Burgat-Sacaze

Abstract

Groups of 5 male and 4 female Cobs CD rats weighing 250--350 g were injected intraperitoneally, daily for 15 days, with 5 mumol HgCl2/kg, 5 mumol Na2SeO3/kg, or (5 mumol HgCl2 + 5 mumol Na2SeO3)/kg in a 10 ml/kg vol. of saline. Control animals were injected with saline only. Injection of saline or sodium selenite produced neither modification of diuresis, nor of urine elimination of sodium, potassium, chloride, phosphates, urea, creatinine and gamma-glutamyl transferase (GGT). Injection of mercuric chloride induced a massive increase of urine GGT, diuresis and phosphaturia and a decrease of kaliuria and natriuria. Those effects reflect a kidney tubular lesion which seems to be more severe in males than in females. Injection of mixed sodium selenite and mercuric chloride or separate injection of both compounds had similar effects. In both sexes, urine GGT elimination was delayed and about 2 times lower than with HgCl2 alone. In females, the other urine parameters were almost normal whereas in males, diuresis and phosphaturia were slightly increased and kaliuria decreased. The observation of urine GGT elimination attests, in vivo, that sodium selenite decreases tubular toxicity of mercuric chloride and resulting kidney function d...Continue Reading

References

Mar 1, 1980·Toxicology Letters·S DurandJ P Braun
Mar 1, 1981·Toxicology Letters·M KassabiA G Rico
Mar 1, 1982·Toxicology Letters·J M HuguetA G Rico
Aug 1, 1992·Journal of Toxicology and Environmental Health·M P DieterL C Uraih
Oct 6, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Periandavan KalaiselviPalaninathan Varalakshmi
Sep 22, 2015·Journal of Pharmacopuncture·Manickam Kalappan VanithaDhanapal Sakthisekaran
Sep 30, 2008·Journal of Applied Toxicology : JAT·Xiaolei JinRekha Mehta
Feb 9, 2010·Current Eye Research·R ManikandanM Arumugam
Aug 24, 2011·Toxicology and Industrial Health·Memy H HassanAbdel-Aziz Hamed
Nov 21, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·P AnandakumarT Devaki
Mar 7, 2017·Frontiers in Pharmacology·Xiu-Fen LiuDan-Dan Zhou

Related Concepts

Urine
Creatinine
Selenium
Gamma-glutamyl transferase
Potassium
Diuresis
Weighing Patient
Mercuric chloride
Sodium Selenite
Toxicology

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.