Urine profiles and kidney histology after intravenous injection of ionic and nonionic radiologic and magnetic resonance contrast media in normal rats

Academic Radiology
H S ThomsenO Svendsen

Abstract

Previous studies showed that both high-osmolality and low-osmolality iodinated contrast media cause temporary albuminuria and enzymuria (presence of enzymes in urine) in normal rats. Whether the same is true with ionic high-osmolality and nonionic low-osmolality magnetic resonance (MR) contrast media is unknown. We studied urine profiles and histology after intravenous injection of four types of contrast media in rats with normal kidneys. Urine profiles were monitored 4, 24, 48, and 72 hr after intravenous injection of saline, diatrizoate, iohexol, gadopentetate dimeglumine, and gadodiamide (4.59 mmol/kg of body weight) in normal rats. Each group included 20 male rats. After sacrifice, both kidneys were removed for examination by light microscopy (LM) and electron microscopy (EM). All four contrast agents caused a temporary (< 22 hr) increase in the excretion of albumin (2-5 times) and of cytoplasmic (30-100 times) and brush border (10-100 times) renal enzymes when compared with saline. The degree of albuminuria correlated well (r = 0.90) with the osmolality of the injected media, whereas the increased level of enzymuria was unrelated to the osmolality. No major differences in the enzymuric effects of the four agents were noted...Continue Reading

Citations

Aug 10, 2001·Investigative Radiology·M WasakiK Shirota
Aug 1, 1996·Academic Radiology·H S ThomsenO Svendsen
Apr 26, 2007·Journal of Magnetic Resonance Imaging : JMRI·Shao-Pow Lin, Jeffrey J Brown
Oct 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Hale Ersoy, Frank J Rybicki
Oct 18, 2016·Topics in Magnetic Resonance Imaging : TMRI·James R CostelloDiego R Martin
Jun 28, 2012·Human & Experimental Toxicology·C-C ChienJ-J Wang
Oct 13, 2009·Postgraduate Medicine·Hariprasad TrivediRuchika Batwara

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