Urine protein markers distinguish stone-forming from non-stone-forming relatives of calcium stone formers

American Journal of Physiology. Renal Physiology
Kristin J BergslandFredric L Coe

Abstract

We have investigated urine protein inhibitors of calcium oxalate crystallization to determine whether variations in these proteins are associated with kidney stone disease and whether protein measurements improve the identification of stone formers compared with conventional risk factors (RF). Using Western blotting, we studied variations in the electrophoretic mobility patterns and relative abundances of crystallization-inhibitory proteins in urine from 50 stone-forming (SF) and 50 non-stone-forming (NS) first-degree relatives of calcium SF patients, matched by gender and age. Standard urine chemistry stone risk measurements were also made. Multivariate discriminant analysis was used to test the association of these proteins with nephrolithiasis. Differences in form and abundance of several urine proteins including inter-alpha-trypsin inhibitor (ITI), prothrombin fragment 1 (PF1), CD59, and calgranulin B (calB) were found to be associated with stone formation. By multivariate discriminant analysis, measurements of forms of PF1, ITI, and calB in men and ITI and CD59 in women, classified 84% of men and 76% of women correctly by stone status. In contrast, standard urine chemistry RF identified only 70% of men correctly and failed...Continue Reading

References

Jul 1, 1986·Kidney International·J H Parks, F L Coe
Dec 1, 1985·The Journal of Urology·P G WernessB Finlayson
Oct 1, 1993·Kidney International·A M StapletonR L Ryall
Jan 1, 1995·The American Journal of Medicine·F L LevyC Y Pak
Apr 1, 1996·The Biochemical Journal·J P SalierM Daveau
Mar 1, 1997·Current Opinion in Nephrology and Hypertension·R J Johnson
Feb 7, 1998·Kidney International·J R AsplinJ R Hoyer
Mar 7, 1998·Biochemistry·R J PetrovanJ Rosing
Dec 29, 1998·The Journal of Biological Chemistry·A M BlomE Fries
May 8, 1999·Journal of the American Society of Nephrology : JASN·S IidaS R Khan
Sep 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A GlauserB Hess
Jan 3, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R C HedgepethS R Marengo
Jan 10, 2001·Current Opinion in Urology·C F Verkoelen, M S Schepers
Apr 20, 2001·Journal of Protein Chemistry·A KurataM Tashiro
Mar 6, 2003·The Journal of Clinical Investigation·Andrew P EvanMarc Grynpas
Mar 20, 2003·Microscopy Research and Technique·Wolfgang NackenClaus Kerkhoff
Aug 26, 2003·Journal of the American Society of Nephrology : JASN·Daniel TurnbergH Terence Cook
Feb 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael J PugiaJohn A Lott

❮ Previous
Next ❯

Citations

Aug 15, 2008·American Journal of Physiology. Renal Physiology·Michael L MerchantEleanor D Lederer
Jul 23, 2013·PloS One·Nobuaki OkumuraToshifumi Takao
Feb 24, 2012·Kidney International·Kristin J BergslandJohn R Asplin
May 20, 2008·Primary Care·Elaine M Worcester, Fredric L Coe
Dec 18, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chanchai BoonlaKerstin Krieglstein
Feb 1, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Supaporn KhamchunVisith Thongboonkerd
Dec 14, 2007·American Journal of Physiology. Renal Physiology·Phulwinder K GroverRosemary L Ryall
Sep 28, 2007·American Journal of Physiology. Renal Physiology·Lan MoXue-Ru Wu
Mar 30, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Thasinas DissayabutraPiyaratana Tosukhowong
Feb 6, 2008·Journal of the American Chemical Society·Lianli ChiRobert J Linhardt
Nov 16, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Eugenia Awuah BoadiBidhan C Bandyopadhyay
Mar 1, 2007·Diabetes Care·Paturi V RaoSrinivasa R Nagalla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.