Urine tested positive for ethyl glucuronide and ethyl sulfate after the consumption of yeast and sugar

Forensic Science International : Synergy
Annette ThieraufWolfgang Weinmann

Abstract

To an increasing degree, EtG and EtS are routinely used for the proof of abstinence for purposes of traffic, occupational, addiction and social medicine. This routine use demands further investigations on the sensitivity and specificity of these analytes and the examination of possible genesis of positive EtG and EtS concentrations even without the consumption of ethanol. In vivo fermentation with consecutive formation of EtG and EtS was addressed by experiments with yeast products. Two experiments with baker's yeast and brewer's yeast tablets were performed. The ethanol concentrations in urine of the 2 and 4 volunteers, respectively, were detected by HS-GC-FID, EtG and EtS analysis was performed by LC-ESI-MS/MS, and the creatinine concentration was determined using a method based on the Jaffé reaction. After the consumption of baker's yeast the maximum concentrations of EtG and EtS normalised to creatinine were found to be 0.67 and 1.41mg/L, respectively, and therefore clearly above the commonly applied cut-off value for the proof of abstinence of 0.1mg/L. In contrast, in this study the, uptake of yeast tablets did not result in a detection of EtG and EtS in urine.

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Citations

Sep 13, 2012·Expert Review of Proteomics·Mariana P TorrenteKent E Vrana
Nov 10, 2012·Forensic Science International : Synergy·Torsten ArndtKarsten Stemmerich
Sep 8, 2015·Alcoholism, Clinical and Experimental Research·Friedrich M WurstWolfgang Weinmann
Aug 3, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Katharina StauferMartina Sterneck
Jun 5, 2013·Alcoholism, Clinical and Experimental Research·Gregory E SkipperFriedrich M Wurst
May 7, 2014·BioMed Research International·Tamme W GoeckeJohannes Kornhuber
Jul 15, 2015·International Journal of Legal Medicine·Annette Thierauf-EmbergerLaura M Huppertz
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Sep 15, 2010·International Journal of Legal Medicine·Frank MusshoffBurkhard Madea
Apr 15, 2016·World Journal of Gastroenterology : WJG·Katharina Staufer, Michel Yegles
Mar 16, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Hilke Andresen-StreichertMartina Sterneck
Nov 16, 2020·Alcoholism, Clinical and Experimental Research·Janique ArntsJef Verbeek

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