Urine transforming growth factor-beta activity is related to the degree of scarring in crescentic nephritis in the rabbit

Nephron
J W NohS H Phan

Abstract

Crescentic nephritis was induced in rabbits by injection of antirabbit glomerular basement membrane (GBM) antibodies. Urine samples were obtained by catheterization and assayed for transforming growth factor-beta (TGF-beta) activity. On day 31, all animals were sacrificed for evaluation of renal cortical histopathology and collagen content. The results show that control rabbit urine contains measurable amounts of TGF-beta. Urine TGF-beta activity was expressed in relation to urine creatinine concentration to correct for variation in urine concentration. When expressed in this manner, urine TGF-beta activity increased from day 2 onwards, peaked on day 7 and returned to normal levels after day 14. This time course is identical to that previously seen for the cortical and glomerular production of TGF-beta in the same model. Furthermore, when the normalized TGF-beta values for each animal were compared to their respective fibrosis parameters on day 31, significant correlations were observed for the values of urine TGF-beta activities on day 7 and all indices of fibrosis. These results suggest that measurements of urine TGF-beta activity at certain critical stages of disease could be useful in predicting the progression to end-stage...Continue Reading

Citations

Jun 8, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·M OtsA Tamm
Dec 21, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·D R ChaN H Kim
May 9, 2006·American Journal of Nephrology·Sotiris Tsakas, Dimitrios S Goumenos
Mar 13, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hyeong Cheon ParkDae Suk Han
Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R HaramakiS Okuda
Jul 9, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Claudia do C MaquiaveliTerezila M Coimbra
Jun 6, 2018·The Journal of International Medical Research·Yamei Wang, Yuhong Tao
Apr 19, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Akihiro FukudaShouichi Fujimoto
Jun 1, 1996·Scandinavian Journal of Urology and Nephrology·K N LaiP K Li
Dec 10, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E W RivarolaT M Coimbra

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