Urine: Waste product or biologically active tissue?

Neurourology and Urodynamics
Urinology Think Tank Writing Group

Abstract

Historically, urine has been viewed primarily as a waste product with little biological role in the overall health of an individual. Increasingly, data suggest that urine plays a role in human health beyond waste excretion. For example, urine might act as an irritant and contribute to symptoms through interaction with-and potential compromise of-the urothelium. To explore the concept that urine may be a vehicle for agents with potential or occult bioactivity and to discuss existing evidence and novel research questions that may yield insight into such a role, the National Institute of Diabetes and Digestive and Kidney Disease invited experts in the fields of comparative evolutionary physiology, basic science, nephrology, urology, pediatrics, metabolomics, and proteomics (among others) to a Urinology Think Tank meeting on February 9, 2015. This report reflects ideas that evolved from this meeting and current literature, including the concept of urine quality, the biological, chemical, and physical characteristics of urine, including the microbiota, cells, exosomes, pH, metabolites, proteins, and specific gravity (among others). Additionally, the manuscript presents speculative, and hopefully testable, ideas about the functional ...Continue Reading

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Citations

Dec 17, 2017·The Journal of Urology·Jenna M NortonTamara Bavendam
May 23, 2020·Journal of Cellular and Molecular Medicine·Xiao Jian XiHua Mi
May 14, 2020·Journal of Clinical Medicine·Konrad FutymaTomasz Rechberger
Jan 24, 2019·Therapeutic Advances in Urology·Karol Borys TudrejMałgorzata Kozłowska-Wojciechowska
Jun 10, 2021·Journal of the American Society for Mass Spectrometry·Cristina Di PotoLisa H Cazares

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