Urocortin 1 inhibits rat leydig cell function.

Endocrinology
C Rivier

Abstract

Corticotropin-releasing factor (CRF) has previously been reported in rat testes in which it inhibits Leydig cells activity. However, recent studies in our laboratory have suggested that some of the effects originally attributed to CRF were instead due to the related peptide Urocortin 1 (Ucn 1) and that this latter hormone, not CRF, was detectable in Leydig cells. We show here that Ucn 1 [a mixed CRF receptor (CRFR) type 1 and CRFR2 agonist] and the CRFR1-selective peptide Stressin 1, but not Ucn 2 or Ucn 3 (both considered selective CRFR2 ligands), significantly blunt the testosterone response to human chorionic gonadotropin. The effect of Ucn 1 is observed regardless of whether this peptide is injected iv or directly into the testes, and it is reversed by the mixed CRFR1/R2 antagonist Astressin B. Blockade of GnRH receptors with the antagonist Azalin B does not interfere with the influence of Ucn 1, thereby demonstrating that pituitary luteinizing hormone does not appear to be involved in this model. Collectively these results suggest that Ucn 1, not CRF, is present in the rat testes and interferes with Leydig cell activity. However, whereas we previously reported that alcohol up-regulated gonadal Ucn 1 gene expression, CRF re...Continue Reading

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Citations

Jun 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth D KirbyDaniela Kaufer
Nov 1, 2008·Integrative and Comparative Biology·Takayoshi UbukaGeorge E Bentley
May 15, 2008·Proceedings. Biological Sciences·Timothy J GreivesGregory E Demas
May 27, 2014·Reproductive Biology·Adriana De LucaNicola Mirabella
Jan 25, 2011·Neuropeptides·Soon LeeCatherine Rivier
Nov 30, 2010·Neuropeptides·Camryn D AllenCatherine Rivier
Aug 6, 2013·Hormones and Behavior·Jill E SchneiderErin Keen-Rhinehart
Jun 11, 2016·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Caterina SquillaciotiNicola Mirabella
Sep 25, 2017·Alcoholism, Clinical and Experimental Research·Matthew B PomrenzeRobert O Messing
Oct 6, 2019·Acta Veterinaria Scandinavica·Caterina SquillaciotiNicola Mirabella

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