Urodilatin excretion and its correlation with sodium excretion in healthy full-term newborn infants

Early Human Development
Rosa ManganaroMarina Gemelli

Abstract

Urodilatin (URO) is a member of the natriuretic family, cleaved by the kidney, which acts as a paracrine hormone in the regulation of natriuresis and diuresis. In newborn infants the excretion of urodilatin and its biological effects have not been explored. We measured urinary URO excretion, by direct RIA (radioimmunoassay), as well as its correlation to neonatal body weight loss, and sodium homeostasis in 30 full-term newborn infants on the 4th day of life. The URO excretion, estimated as URO:creatinine ratio, was significantly correlated to sodium excretion. These data show that in full-term newborn infants the mechanisms that control synthesis, excretion and signal transduction of URO are developed and that URO contributes to natriuresis regulation.

References

Dec 1, 1991·Acta paediatrica Scandinavica·M GemelliF Martino
Jan 1, 1988·Biology of the Neonate·J E Robillard, K T Nakamura
Nov 1, 1994·Pediatric Research·A Bueva, J P Guignard
Oct 30, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M HertenC Drummer

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Citations

Jun 5, 2007·Protein Expression and Purification·Ziyong SunJian-Ning Liu
Oct 12, 2007·Neonatal Network : NN·Jodi M Beachy
Oct 12, 2013·Tropical Medicine & International Health : TM & IH·Carolyn G ScraffordJames M Tielsch
Nov 5, 2013·American Journal of Epidemiology·Lisu HuangJun Zhang

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