Urodynamic and morphologic changes in the lower portion of the urogenital tract after administration of estriol alone and in combination with phenylpropanolamine in sexually intact and spayed female dogs

American Journal of Veterinary Research
Annick J HamaideJohn P Verstegen

Abstract

To compare the urodynamic and morphologic effects of the administration of estriol alone and in combination with phenylpropanolamine on the lower portion of the urogenital tract in female dogs. 3 sexually intact and 3 spayed female Beagles without urinary incontinence. Dogs received estriol (2 mg, PO) once daily for 7 days followed by estriol (2 mg, PO) and phenylpropanolamine (1.5 mg/kg, PO) once daily for 7 days. Urethral pressure profilometry, diuresis cystometry, and vaginourethrography were performed before treatment (day 0) and at days 7 and 14. The maximum urethral pressure (MUP) and closure pressure (MUCP), urethral functional and anatomic profile lengths, integrated pressure (IP), plateau, distance before MUP, maximum meatus pressure, threshold pressure, threshold volume, compliance, urethral length, and vaginal length and width were measured. Before treatment, no urodynamic differences were observed between the 2 groups; however, vaginal length and width were significantly shorter in spayed dogs. Compared with day 0 values, estriol treatment significantly increased MUP, MUCP, and IP values at day 7, but at day 14, this effect decreased despite phenylpropanolamine administration. No morphologic changes from baseline we...Continue Reading

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Apr 4, 2006·American Journal of Veterinary Research·Francesca CarofiglioJohn P Verstegen

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Citations

Nov 21, 2012·Veterinary Surgery : VS·Lauren ReevesDennis Chew
Apr 1, 2015·The Veterinary Clinics of North America. Small Animal Practice·Julie K Byron
Nov 14, 2012·Journal of the American Animal Hospital Association·Jennifer A GinnRebecca L Stepien

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