Urodynamic changes in mice with experimental autoimmune encephalomyelitis correlate with neurological impairment

Neurourology and Urodynamics
J FrankenD De Ridder

Abstract

Neurogenic bladder dysfunction is a major issue in Multiple Sclerosis (MS). High intravesical pressure should be treated early. Available therapies are insufficient and there is need for drug development and investigation of pathogenesis. Experimental Autoimmune Encephalomyelitis (EAE) in rodents is a well validated model to study MS. Previous research has shown that these animals develop urinary symptoms. However, from clinical studies, we know that symptoms do not necessarily reflect changes in bladder pressure. This paper aims to provide a complete overview of urodynamic changes in a model for detrusor overactivity in MS. Female C57Bl/6J mice, injected with MOG35-55 and control mice, injected with vehicle (Complete Freund's adjuvant), were monitored daily for neurologic symptoms. Within 1 month after symptom development, mice were used for cystometry or histology of the bladder. Increasing disease score correlated with increased micturition frequency, basal pressure, and average pressure, and with a decrease in functional bladder capacity, voiding amplitude, and maximum pressure. This paper provides a detailed description of bladder function in C57Bl/6J mice with Myelin Oligodendrocyte Glycoprotein peptide (MOG35-55 ) induce...Continue Reading

References

Mar 1, 1978·Neuropathology and Applied Neurobiology·D R Oppenheimer
Jun 1, 1991·The Journal of Urology·B L BemelmansF M Debruyne
Feb 18, 1999·The Journal of Urology·S E LitwillerP E Zimmern
Apr 17, 2002·Lancet·Alastair Compston, Alasdair Coles
Aug 28, 2003·Lancet Neurology·Geert LycklamaFrederik Barkhof
Aug 16, 2008·Journal of Neuroimmunology·Cengiz Z AltuntasVincent K Tuohy
Jun 30, 1933·The Journal of Experimental Medicine·T M RiversG P Berry
Jun 19, 2010·Progress in Neurobiology·Eilhard MixUwe K Zettl
Jun 24, 2010·Expert Opinion on Drug Safety·Richard NicholasTim Friede
Mar 5, 2011·British Journal of Pharmacology·Cris S ConstantinescuBruno Gran
Jun 11, 2011·Neurourology and Urodynamics·Karl-Erik AnderssonClaudius Füllhase
Jul 6, 2013·Scientific Reports·Hiromitsu NegoroSylvia O Suadicani
Oct 25, 2013·American Journal of Physiology. Renal Physiology·Rui XueJinjian Yang
May 7, 2014·Journal of Visualized Experiments : JoVE·Stefan BittnerSven G Meuth
Jun 6, 2015·The Cochrane Database of Systematic Reviews·Richard S NicholasCarolyn A Young

❮ Previous
Next ❯

Citations

May 26, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yafei YangHaifeng Hu
Aug 5, 2018·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Ryuji Sakakibara
Mar 20, 2021·Neurourology and Urodynamics·Ramalakshmi Ramasamy, Phillip P Smith

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.