Abstract
To determine lower urinary tract symptoms (LUTS) prevalence and urodynamic findings in amyotrophic lateral sclerosis (ALS) patients treated in our hospital. Cross-sectional and descriptive study on a cohort of ALS patients. Validated questionnaires (ICIQ-SF, IPSS, and OAB-V8) were self-administered in order to evaluate the presence of LUTS. Symptoms were classified as clinically significant (csLUTS), if any of following scores, IPSS > 7, ICIQ-SF > 0, or OAB-V8 ≥ 8, were present. Urodynamic study was offered to csLUTS patients. Physical examination and prostate ultrasound were also performed. Fifty five of seventy nine (70%) ALS patients accepted to participate in the study. Only 24/55 (43.6%) patients met criteria for csLUTS and 13 patients reported urgency urinary incontinence (26.3%). Most of csLUTS patients complained of mixed symptoms (82.6%). QoL measured by IPSS was 2.1 ± 1.5, 20% scoring as mostly dissatisfied or unhappy. Average QoL ICIQ-SF scoring was 3.17 ± 3, 33% complained of moderate to severe bother. Ten of twenty four (41.7%) csLUTS patients consented to UDS. The most frequent finding was detrusor overactivity with obstruction due to non-relaxing external sphincter (five patients) or bladder neck (two patients). ...Continue Reading
References
Apr 1, 1992·Brain : a Journal of Neurology·C E PringleG C Ebers
May 1, 1990·Paraplegia·H Madersbacher
Oct 8, 1998·Urology·X BadíaM Serra
Dec 14, 1999·Journal of the Neurological Sciences·J M CedarbaumA Nakanishi
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B R BrooksUNKNOWN World Federation of Neurology Research Group on Motor Neuron Diseases
Feb 22, 2002·Neurourology and Urodynamics·Paul AbramsUNKNOWN Standardisation Sub-committee of the International Continence Society
Jul 13, 2002·American Journal of Obstetrics and Gynecology·Paul AbramsAlan Wein
Mar 20, 2004·Medicina clínica·Montserrat Espuña PonsMontserrat Puig Clota
Sep 13, 2005·Current Opinion in Neurology·Rositsa BaltadzhievaAmos D Korczyn
Apr 11, 2007·Archives of Neurology·Jeldican VisserMarianne de Visser
Dec 17, 2008·Neuromuscular Disorders : NMD·M M van der GraaffM de Visser
Oct 5, 2010·Neurourology and Urodynamics·Josef MarencakIan W Mills
Apr 22, 2011·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Maria Laura Lopes de CarvalhoGiampaolo Brichetto
Sep 15, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies· Markus Weber
Apr 5, 2012·Neurourology and Urodynamics·Oleg LoutochinJacques Corcos
Feb 19, 2013·Lancet Neurology·Martin R TurnerMatthew C Kiernan
May 21, 2013·Annals of Neurology·Johannes BrettschneiderJohn Q Trojanowski
Feb 1, 2014·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Georg S NüblingAndrea S Winkler
Apr 15, 2014·Medicina clínica·Francisco J BrenesIsabel Lizarraga
Jun 12, 2014·Acta Neuropathologica·Johannes BrettschneiderJohn Q Trojanowski
Citations
Dec 17, 2016·Expert Review of Neurotherapeutics·P A McCombeR D Henderson
Nov 7, 2017·Muscle & Nerve·Yuki NakayamaEiji Isozaki
Dec 6, 2019·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Takahiro TakedaKimihito Arai
Sep 12, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Sabrina PaganoniGracy Juba
Mar 15, 2018·Frontiers in Neurology·René GüntherAndreas Hermann
Nov 10, 2018·Frontiers in Neuroscience·Miguel MazónLuis Martí-Bonmatí
Apr 28, 2021·Revue neurologique·P CouratierP Corcia
May 17, 2021·CNS Drugs·Colin J MahoneyMatthew C Kiernan
May 25, 2021·Journal of Neuromuscular Diseases·Yuval Nash, Michal Sitty
Jun 29, 2021·Journal of the Neurological Sciences·Verena C SamaraMark Bromberg