Urodynamic findings in amyotrophic lateral sclerosis patients with lower urinary tract symptoms: Results from a pilot study

Neurourology and Urodynamics
Salvador ArlandisEnrique Broseta

Abstract

To determine lower urinary tract symptoms (LUTS) prevalence and urodynamic findings in amyotrophic lateral sclerosis (ALS) patients treated in our hospital. Cross-sectional and descriptive study on a cohort of ALS patients. Validated questionnaires (ICIQ-SF, IPSS, and OAB-V8) were self-administered in order to evaluate the presence of LUTS. Symptoms were classified as clinically significant (csLUTS), if any of following scores, IPSS > 7, ICIQ-SF > 0, or OAB-V8 ≥ 8, were present. Urodynamic study was offered to csLUTS patients. Physical examination and prostate ultrasound were also performed. Fifty five of seventy nine (70%) ALS patients accepted to participate in the study. Only 24/55 (43.6%) patients met criteria for csLUTS and 13 patients reported urgency urinary incontinence (26.3%). Most of csLUTS patients complained of mixed symptoms (82.6%). QoL measured by IPSS was 2.1 ± 1.5, 20% scoring as mostly dissatisfied or unhappy. Average QoL ICIQ-SF scoring was 3.17 ± 3, 33% complained of moderate to severe bother. Ten of twenty four (41.7%) csLUTS patients consented to UDS. The most frequent finding was detrusor overactivity with obstruction due to non-relaxing external sphincter (five patients) or bladder neck (two patients). ...Continue Reading

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Citations

Dec 17, 2016·Expert Review of Neurotherapeutics·P A McCombeR D Henderson
Dec 6, 2019·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Takahiro TakedaKimihito Arai
Sep 12, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Sabrina PaganoniGracy Juba
Apr 28, 2021·Revue neurologique·P CouratierP Corcia
May 25, 2021·Journal of Neuromuscular Diseases·Yuval Nash, Michal Sitty
Jun 29, 2021·Journal of the Neurological Sciences·Verena C SamaraMark Bromberg

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