PMID: 2112644May 1, 1990Paper

Urogastrone reduces gut atrophy during parenteral alimentation

JPEN. Journal of Parenteral and Enteral Nutrition
L E BraggJ S Thompson

Abstract

Urogastrone (UG) exerts trophic effects on the intestine and may play a role in maintaining normal intestinal structure and function. Since administration of nutrients parenterally results in intestinal hypoplasia and hypofunction, the aim of this study was to determine the effects of UG on intestinal structure and function in parenterally fed rats. Central venous catheters were placed into 28 Sprague-Dawley rats. Group I (n = 10) received TPN alone. Group II (n = 8) received TPN and 15 micrograms/day of UG and group III (n = 10) received rat chow ad libitum. The animals that received urogastrone had significantly greater (p less than 0.05) intestinal weight (25.6 +/- 2.5 mg/cm vs 22.6 +/- 3.0 mg/cm), mucosal weight (8.4 +/- 1.4 mg/cm vs 6.2 +/- 0.9 mg/cm), mucosal protein content (6.2 +/- 1.7 mg/cm vs 2.7 +/- 0.6 mg/cm), villous height (427 +/- 27 microns vs 293 +/- 75 microns), crypt cell production rate (14.5 +/- 1.4 metaphases/hr vs 12.3 +/- 0.7 metaphases/hr) and sucrase specific activity (6.5 +/- 2.6 vs 3.7 +/- 2.0) than animals receiving only TPN. However, these parameters remained less than in chow-fed animals. Thus, simultaneous infusion of UG prevents, in part, intestinal hypofunction and hypoplasia which occurs durin...Continue Reading

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Citations

Jan 1, 1994·Baillière's Clinical Endocrinology and Metabolism·R G Taylor, P J Fuller
Jun 24, 2008·International Journal of Radiation Oncology, Biology, Physics·Kang Kyoo LeeSun Rock Moon
Mar 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·Y InoueP J Snyder
Sep 14, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·J S Thompson
Sep 14, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·W M Wong, N A Wright
Feb 24, 1999·Inflammatory Bowel Diseases·P L Beck, D K Podolsky
Apr 28, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Richard SalvinoEzra Steiger

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