Urogenital and pelvic complications in the Ehlers-Danlos syndromes and associated hypermobility spectrum disorders: A scoping review

Clinical Genetics
Elizabeth GilliamGloria Yeh

Abstract

The Ehlers-Danlos syndromes (EDS) and associated hypermobility spectrum disorders (HSD) are a heterogenous group of connective tissue disorders associated with significant morbidity. The urogenital aspects of these disorders are understudied and there is little guidance on the prevalence, types, or outcomes of urogenital complications in EDS/HSD. Our objective was to perform a scoping review to characterize and synthesize the literature reporting urogenital and pelvic complications in EDS/HSD patients. We performed a systematic search of three databases (Medline, CINAHL, Embase) to January 2019. English language, full-text articles reporting on urogenital or pelvic complications in EDS/HSD were included. A total of 105 studies were included (62 case reports/series, 43 observational) involving patients with hypermobile (23%), vascular (20%), classical (12%) EDS, and HSD (24%). Some studies looked at multiple subtypes (11%) or did not report subtype (33%). Reported complications included urinary (41%), gynecological (36%), obstetrical (25%), renal (9%), and men's health problems (7%), with some studies reporting on multiple areas. Urinary and gynecological complications were most prevalent in patients with HSD, while a broad rang...Continue Reading

References

Nov 1, 1979·Clinical Genetics·A HernándezJ M Cantú
Jan 1, 1992·European Journal of Clinical Pharmacology·M S al-GhamdiI S al-Saeed
Dec 1, 1992·Urology·K H Stage, E S Tank
Jan 1, 1989·Pediatric Radiology·T ToyoharaT Nakamura
Nov 1, 1989·Journal of Pediatric Surgery·E Schippers, H J Dittler
Nov 1, 1989·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A De PaepeM Matton
Oct 1, 1988·Cardiovascular and Interventional Radiology·T KahnA Heuck
Mar 1, 1988·American Journal of Medical Genetics·P BeightonV A McKusick
Mar 1, 1988·Journal of Neurosurgery·K Hegedüs
Aug 1, 1985·Zeitschrift Für Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Für Kinderchirurgie = Surgery in Infancy and Childhood·N BreivikP Vesterhus
Feb 1, 1969·The Journal of Obstetrics and Gynaecology of the British Commonwealth·P Beighton
Jun 1, 1967·British Journal of Urology·D G Eadie, J L Wilkins
Dec 1, 1969·The American Journal of Medicine·S ImahoriJ C Brennan
Jul 1, 1968·Annals of the Rheumatic Diseases·F CosteL Chouraki
Sep 15, 1968·American Journal of Obstetrics and Gynecology·F J Stoddard, R E Myers
Jun 26, 1982·Lancet·Z S AL-Rawi, Z T Al-Rawi
Jan 1, 1983·Lancet·N L RuddP H Byers
Sep 1, 1983·Asia-Oceania Journal of Obstetrics and Gynaecology·Y NakamuraM Nagayama
Apr 1, 1982·Annals of the Rheumatic Diseases·M CalguneriV Wright
Jan 1, 1995·Nephron·A K Ghosh, T O'Bryan
Feb 1, 1995·Obstetrics and Gynecology·P A NortonJ C Warenski
Dec 1, 1993·Clinical Obstetrics and Gynecology·P A Norton
Apr 1, 1993·Injury·A M WainwrightP J Gregg
Aug 1, 1993·Acta Paediatrica Japonica; Overseas Edition·T SatoY Hayashida
Feb 1, 1996·American Journal of Obstetrics and Gynecology·C W SchaubergerA Schaper
Apr 1, 1997·British Journal of Obstetrics and Gynaecology·M S GeorgyD H Redford
Dec 23, 1998·Clinical and Experimental Dermatology·N P BurrowsF M Pope
Apr 22, 1999·Journal of Pediatric Surgery·J L Jorion, M Michel
Jun 3, 1999·The British Journal of Dermatology·S C Tucker, J A Yell
Dec 22, 1999·Advances in Experimental Medicine and Biology·C M DeveaudP S Howard
Mar 9, 2000·The New England Journal of Medicine·M PepinP H Byers
May 20, 2000·American Journal of Obstetrics and Gynecology·M E Carley, J Schaffer
May 22, 2001·The British Journal of Dermatology·S HandaV K Sharma
Oct 12, 2001·Clinical Genetics·F GolfierH Plauchu
Apr 16, 2002·Acta Obstetricia Et Gynecologica Scandinavica·Jan Lind, Henk C S Wallenburg
Dec 18, 2002·Spine·Hanne B AlbertJes G Westergaard
Jul 10, 2003·International Urogynecology Journal and Pelvic Floor Dysfunction·J ManningM Solomon
Feb 1, 1956·A.M.A. Archives of Dermatology·Z LEWITUS
Nov 1, 1961·The American Journal of the Medical Sciences·H J DAY, C J ZARAFONETIS
Oct 9, 2003·The Journal of Urology·Laetitia M O de KortTom P V M de Jong
Oct 31, 2003·American Journal of Obstetrics and Gynecology·Keren OfirMoshe Mazor
Dec 4, 2003·Archives of Gynecology and Obstetrics·Ayse KaranOnay Yalcin

❮ Previous
Next ❯

Citations

Jun 2, 2020·Molecular Genetics & Genomic Medicine·Julie GomezHuda B Al-Kouatly
Sep 25, 2020·Children·Estée C H FeldmanRachel Neff Greenley
Mar 21, 2021·Current Opinion in Rheumatology·Deeba Minhas
Jun 14, 2021·Journal of Pediatric and Adolescent Gynecology·E P A Brander, J E Dietrich
Nov 9, 2021·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Jennifer E GlayzerJudith M Schlaeger
Nov 21, 2021·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Mittal Patel, Vik Khullar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Periodontology
Ines Kapferer-SeebacherJohannes Zschocke
Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Peter J De CosterA De Paepe
© 2021 Meta ULC. All rights reserved