Urogenital and pelvic complications in the Ehlers-Danlos syndromes and associated hypermobility spectrum disorders: A scoping review

Clinical Genetics
Elizabeth GilliamGloria Yeh


The Ehlers-Danlos syndromes (EDS) and associated hypermobility spectrum disorders (HSD) are a heterogenous group of connective tissue disorders associated with significant morbidity. The urogenital aspects of these disorders are understudied and there is little guidance on the prevalence, types, or outcomes of urogenital complications in EDS/HSD. Our objective was to perform a scoping review to characterize and synthesize the literature reporting urogenital and pelvic complications in EDS/HSD patients. We performed a systematic search of three databases (Medline, CINAHL, Embase) to January 2019. English language, full-text articles reporting on urogenital or pelvic complications in EDS/HSD were included. A total of 105 studies were included (62 case reports/series, 43 observational) involving patients with hypermobile (23%), vascular (20%), classical (12%) EDS, and HSD (24%). Some studies looked at multiple subtypes (11%) or did not report subtype (33%). Reported complications included urinary (41%), gynecological (36%), obstetrical (25%), renal (9%), and men's health problems (7%), with some studies reporting on multiple areas. Urinary and gynecological complications were most prevalent in patients with HSD, while a broad rang...Continue Reading


Nov 1, 1979·Clinical Genetics·A HernándezJ M Cantú
Jan 1, 1992·European Journal of Clinical Pharmacology·M S al-GhamdiI S al-Saeed
Dec 1, 1992·Urology·K H Stage, E S Tank
Jan 1, 1989·Pediatric Radiology·T ToyoharaT Nakamura
Nov 1, 1989·Journal of Pediatric Surgery·E Schippers, H J Dittler
Nov 1, 1989·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A De PaepeM Matton
Oct 1, 1988·Cardiovascular and Interventional Radiology·T KahnA Heuck
Mar 1, 1988·American Journal of Medical Genetics·P BeightonV A McKusick
Mar 1, 1988·Journal of Neurosurgery·K Hegedüs
Aug 1, 1985·Zeitschrift Für Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Für Kinderchirurgie = Surgery in Infancy and Childhood·N BreivikP Vesterhus
Feb 1, 1969·The Journal of Obstetrics and Gynaecology of the British Commonwealth·P Beighton
Jun 1, 1967·British Journal of Urology·D G Eadie, J L Wilkins
Dec 1, 1969·The American Journal of Medicine·S ImahoriJ C Brennan
Jul 1, 1968·Annals of the Rheumatic Diseases·F CosteL Chouraki
Sep 15, 1968·American Journal of Obstetrics and Gynecology·F J Stoddard, R E Myers
Jun 26, 1982·Lancet·Z S AL-Rawi, Z T Al-Rawi
Jan 1, 1983·Lancet·N L RuddP H Byers
Sep 1, 1983·Asia-Oceania Journal of Obstetrics and Gynaecology·Y NakamuraM Nagayama
Apr 1, 1982·Annals of the Rheumatic Diseases·M CalguneriV Wright
Jan 1, 1995·Nephron·A K Ghosh, T O'Bryan
Feb 1, 1995·Obstetrics and Gynecology·P A NortonJ C Warenski
Dec 1, 1993·Clinical Obstetrics and Gynecology·P A Norton
Apr 1, 1993·Injury·A M WainwrightP J Gregg
Aug 1, 1993·Acta Paediatrica Japonica; Overseas Edition·T SatoY Hayashida
Feb 1, 1996·American Journal of Obstetrics and Gynecology·C W SchaubergerA Schaper
Apr 1, 1997·British Journal of Obstetrics and Gynaecology·M S GeorgyD H Redford
Dec 23, 1998·Clinical and Experimental Dermatology·N P BurrowsF M Pope
Apr 22, 1999·Journal of Pediatric Surgery·J L Jorion, M Michel
Jun 3, 1999·The British Journal of Dermatology·S C Tucker, J A Yell
Dec 22, 1999·Advances in Experimental Medicine and Biology·C M DeveaudP S Howard
Mar 9, 2000·The New England Journal of Medicine·M PepinP H Byers
May 20, 2000·American Journal of Obstetrics and Gynecology·M E Carley, J Schaffer
May 22, 2001·The British Journal of Dermatology·S HandaV K Sharma
Oct 12, 2001·Clinical Genetics·F GolfierH Plauchu
Apr 16, 2002·Acta Obstetricia Et Gynecologica Scandinavica·Jan Lind, Henk C S Wallenburg
Dec 18, 2002·Spine·Hanne B AlbertJes G Westergaard
Jul 10, 2003·International Urogynecology Journal and Pelvic Floor Dysfunction·J ManningM Solomon
Feb 1, 1956·A.M.A. Archives of Dermatology·Z LEWITUS
Nov 1, 1961·The American Journal of the Medical Sciences·H J DAY, C J ZARAFONETIS
Oct 9, 2003·The Journal of Urology·Laetitia M O de KortTom P V M de Jong
Oct 31, 2003·American Journal of Obstetrics and Gynecology·Keren OfirMoshe Mazor
Dec 4, 2003·Archives of Gynecology and Obstetrics·Ayse KaranOnay Yalcin

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