Urogenital schistosomiasis infection prevalence targets to determine elimination as a public health problem based on microhematuria prevalence in school-age children.

PLoS Neglected Tropical Diseases
Ryan E WiegandW Evan Secor

Abstract

Recent research suggests that schistosomiasis targets for morbidity control and elimination as a public health problem could benefit from a reanalysis. These analyses would define evidence-based targets that control programs could use to confidently assert that they had controlled or eliminated schistosomiasis as a public health problem. We estimated how low Schistosoma haematobium infection levels diagnosed by urine filtration in school-age children should be decreased so that microhematuria prevalence was at, or below, a "background" level of morbidity. Data obtained from school-age children in Burkina Faso, Mali, Niger, Tanzania, and Zambia who participated in schistosomiasis monitoring and evaluation cohorts were reanalyzed before and after initiation of preventive chemotherapy. Bayesian models estimated the infection level prevalence probabilities associated with microhematuria thresholds ≤10%, 13%, or 15%. An infection prevalence of 5% could be a sensible target for urogenital schistosomiasis morbidity control in children as microhematuria prevalence was highly likely to be below 10% in all surveys. Targets of 8% and 11% infection prevalence were highly likely to result in microhematuria levels less than 13% and 15%, resp...Continue Reading

References

May 23, 2006·Trends in Parasitology·Narcis B KabatereineLynsey Blair
Aug 4, 2007·The Journal of Infectious Diseases·Artemis KoukounariJoanne P Webster
Feb 20, 2015·PLoS Neglected Tropical Diseases·Charles H King
Nov 25, 2017·The Lancet Infectious Diseases·Joseph B FreerAndrew J Prendergast
Jun 29, 2018·PLoS Neglected Tropical Diseases·Michael D FrenchYaobi Zhang

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