Urogynecological surgical mesh implants: New trends in materials, manufacturing and therapeutic approaches.

International Journal of Pharmaceutics
Zara-Louise FarmerDimitrios A Lamprou

Abstract

Pelvic Organ Prolapse (POP) and Stress Urinary Incontinence (SUI) are two prevalent disorders affecting 30-40% of women worldwide. Current strategies to repair or improve these medical conditions are non-surgical options such as physiotherapy, or surgical options such as the use of vaginal meshes. The synthetic material polypropylene (PP), which has long been used for manufacturing these vaginal meshes, is associated with severe complications such as chronic pain, infection or mesh erosion. As a result of a widespread reporting and unacceptably high rates of complications, these issues have become a public health concern. Regulatory bodies have recently deemed the transvaginal placement of PP mesh in the pelvic floor (PF) no longer a suitable treatment method for PF repair, leading to the need for a novel approach to the manufacture and selection of materials for urogynecological meshes. Medical devices, such as vaginal meshes can be manufactured using a variety of techniques including injection moulding, electrospinning, hot-melt extrusion (HME) or more recently 3D printing. Over the past decade, the use of 3D printing within the medical device industry has expanded and offers a promising approach to manufacture patient-specif...Continue Reading

Citations

Jan 24, 2021·International Journal of Pharmaceutics·Niamh K MartinEneko Larrañeta
Dec 19, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Juliana C QuartermanAliasger K Salem
Aug 16, 2021·International Journal of Pharmaceutics·Sarah A StewartEneko Larrañeta
Aug 28, 2021·International Journal of Pharmaceutics·Raúl Cazorla-LunaDimitrios A Lamprou
Dec 8, 2021·Current Medical Science·Peng-Ran LiuZhe-Wei Ye

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