PMID: 2115769Jul 1, 1990Paper

Urokinase- and tissue-type plasminogen activators are suppressed by cortisol in the involuting prostate of castrated rats

The Biochemical Journal
S N FreemanP A Andreasen

Abstract

The effects of cortisol on the inhibition of cell-death processes and suppression of plasminogen-activator (PA) activity during involution of the rat ventral prostate gland were investigated to determine the principal type of PA activated by castration and inhibited by this hormone and whether the mechanism responsible for decreased PA activity involved reductions in enzyme synthesis or increased activity of a PA inhibitor. By using the technique of fibrin-agarose zymography, three bands of PA activity were detected at 4 and 7 days after castration: a major band with a molecular mass of approx. 30 kDa and two minor bands of 48 kDa and 64 kDa. Both the 30 kDa and 48 kDa activities were inhibited with anti-[urokinase-type PA (u-PA)] IgG. The 64 kDa activity was inhibited by anti-[tissue-type PA (t-PA)] IgG. In addition to retarding prostatic involution, daily administration of cortisol to the castrated animals suppressed all three bands of PA activity. A comparison of the pattern of total PA activity and of e.l.i.s.a. estimates of u-PA concentration during the castration-induced rise and after cortisol inhibition indicated a near perfect correlation between the two parameters. Northern-blot analysis using prostatic polyadenylated...Continue Reading

Citations

Apr 1, 1997·British Journal of Urology·M Tenniswood
Feb 17, 2017·Cell Biology International·Guilherme O BarbosaTaize M Augusto
Sep 1, 1992·Cancer Metastasis Reviews·M P TenniswoodJ E Welsh
Mar 1, 1995·Microscopy Research and Technique·M J Wilson
Apr 1, 1996·Stroke; a Journal of Cerebral Circulation·M KittakaB V Zlokovic
Jun 29, 1999·Endocrinology·C MorrisseyM Tenniswood
Jan 1, 1996·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·D E Terry, A F Clark
Sep 1, 1996·The Prostate·W C PowellG T Bowden
Aug 1, 1998·Biochimica Et Biophysica Acta·M AmbiliP R Sudhakaran

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