PMID: 6989347Feb 1, 1980Paper

Urokinase immobilized on medical polymeric materials: fundamental and clinical studies

Artificial Organs
T Ohshiro, G Kosaki

Abstract

One of the methods of preparing an antithrombogenic material is to immobilize a fibrinolytic enzyme on the surface of a carrier. The clinical trial of such a material must be subject to not only a basic study on the quality of a carrier, the technique of immobilization, and the method of disinfection, but also an in vivo study on its antithrombotic effect. Reported herein is the evaluation of the fibrinolytic ability, at fundamental and clinical levels, of the urokinase that was immobilized on the surface of various polymeric materials. The results were favorable.

Citations

Nov 1, 1995·Medical & Biological Engineering & Computing·Y BenmakrohaP Rolfe
Jun 7, 2011·Annual Review of Biomedical Engineering·Song Li, Jeffrey J D Henry
Mar 1, 1983·Journal of Pharmaceutical Sciences·H P KimS W Kim
Jul 18, 2002·The Journal of Surgical Research·Jian-ming LiBruce S Cutler
Jan 1, 1983·Annals of the New York Academy of Sciences·S W KimH P Kim

Related Concepts

Catheterization
Antithrombin I
Fibrinolysis
Antithrombotic Agents
Supramid
Endopeptidases
Plastics
Polyesters
Spandex
Vinylite

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