PMID: 2497073May 15, 1989Paper

Urokinase-type plasminogen activator biosynthesis is induced by the EJ-Ha-ras oncogene in CL26 mouse colon carcinoma cells

International Journal of Cancer. Journal International Du Cancer
J E TestaB Sordat

Abstract

CL26 murine colon carcinoma cells express urokinase-type plasminogen activator (u-PA) mRNA and activity after transfection with the activated c-Ha-ras-I (EJ-ras) oncogene cloned from the EJ bladder carcinoma. PA activity and mRNA in control cells transfected with the non-mutated c-Ha-ras-I (CO-ras) gene remained negative. Ras mRNA was detected in EJ-ras- and CO-ras-transfected cells, but not in untransfected or pSV2-neo-transfected cells. These results indicate that u-PA biosynthesis can be modulated by EJ-Ha-ras-dependent pathways of signal transduction.

References

Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M WiglerL Chasin
Jan 1, 1985·Advances in Cancer Research·K DanøL Skriver
Apr 1, 1987·The Journal of Cell Biology·F BlasiK Danø
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T NyD J Loskutoff
Jul 15, 1988·International Journal of Cancer. Journal International Du Cancer·S Pereyra-AlfonsoE Bal de Kier Joffé
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S C Bernstein, R A Weinberg
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas
Jan 1, 1983·Cancer Metastasis Reviews·H F DvorakA M Dvorak
Oct 15, 1981·International Journal of Cancer. Journal International Du Cancer·R L O'GradyR W Stephens
Nov 11, 1982·Nature·C J TabinE H Chang

❮ Previous
Next ❯

Citations

Dec 1, 1990·Cancer Metastasis Reviews·J E Testa, J P Quigley
Nov 1, 1992·Cancer Metastasis Reviews·H C Kwaan
Jan 1, 1990·Molecular Aspects of Medicine·T N Dear, R F Kefford
Feb 27, 2004·Biochimica Et Biophysica Acta·Onno KranenburgEmile E Voest
Oct 14, 2011·Nature Reviews. Cancer·Yuliya Pylayeva-GuptaDafna Bar-Sagi
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chun-Fung ChanIrene Oi-Lin Ng
Jun 21, 2021·Journal of Cancer Research and Clinical Oncology·Ruiqi ZhengAihua Gong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.