PMID: 2508479Oct 1, 1989Paper

Urokinase-type plasminogen activator in endothelial cells during acute inflammation of the appendix

The American Journal of Pathology
J Grøndahl-HansenK Danø

Abstract

Urokinase and tissue-type plasminogen activators (u-PA and t-PA) were identified immunohistochemically in normal and inflamed human appendices by means of polyclonal and monoclonal antibodies. In addition, extracts of the tissues were analyzed for u-PA and t-PA by ELISA. Twelve appendices (five normal and seven with acute inflammation) were analyzed. In the normal appendices, there was a strong staining of the endothelial cells for t-PA, whereas there was negative staining for u-PA. In contrast, the endothelial cells in the inflamed appendices showed u-PA immunoreactivity, and negative or very weak reactions for t-PA. In the inflamed appendix, there was also a labeling of u-PA in fibroblast-like cells and in interstitial areas. The specificity of the staining was supported by a variety of staining controls and also by analysis of tissue extracts with ELISA, showing that on the average the inflamed appendices contained more than twice as much mu-PA per mg of protein as the normal appendices and less than one third of the amount of t-PA.

Citations

Oct 2, 1998·Thrombosis Research·H ZoellnerB Binder
Aug 1, 1993·The Journal of Cell Biology·M S PepperJ D Vassalli
Mar 1, 1995·The Laryngoscope·M NakamuraT Morimitsu
Sep 1, 1993·Baillière's Clinical Haematology·S MenashiY Legrand
Jul 10, 2001·The Journal of Clinical Endocrinology and Metabolism·P KoolwijkV W van Hinsbergh
Aug 1, 1996·The British Journal of Surgery·H van GoorR P Bleichrodt

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