Urokinase-type plasminogen activator system and human cationic antimicrobial protein 18 in serum and induced sputum of patients with chronic obstructive pulmonary disease

Respirology : Official Journal of the Asian Pacific Society of Respirology
Yuanyuan JiangYing Xing

Abstract

There is increasing evidence that the innate immune system plays an important role in the pathogenesis of COPD. The objective of this study was to quantify several innate immune biomarkers in serum and induced sputum of COPD patients, and healthy non-smokers and smokers. Serum and induced sputum levels of urokinase-type plasminogen activator (uPA), urokinase-type plasminogen activator receptor (uPAR), urokinase-type plasminogen activator inhibitor (PAI-1) and human cationic antimicrobial protein 18 (CAP18) were measured by ELISA, in 13 patients with stage I or stage II COPD (COPD I + II), 15 patients with stage III or stage IV COPD (COPD III + IV), 18 healthy non-smokers and 14 healthy smokers. In addition, membrane-bound uPAR in peripheral blood and induced sputum was assessed by flow cytometry. Levels of uPAR, PAI-1 and CAP18 were elevated in induced sputum of COPD I + II and COPD III + IV patients, compared with healthy non-smokers (P < 0.05) and healthy smokers (P < 0.05). uPAR, PAI-1 and CAP18 levels were significantly higher in COPD III + IV patients compared with COPD I + II patients (P < 0.05). The expression of uPAR on induced sputum neutrophils and macrophages was significantly higher in COPD patients compared with he...Continue Reading

References

Oct 1, 1991·The Journal of Clinical Investigation·J D VassalliD Belin
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Mar 11, 2000·The Journal of Clinical Investigation·P T DrapkinM J Welsh
Sep 9, 2000·Current Opinion in Cell Biology·L Ossowski, J A Aguirre-Ghiso
Jul 20, 2001·Annals of the New York Academy of Sciences·H R Lijnen
Aug 9, 2001·The European Respiratory Journal·S GompertzR A Stockley
Sep 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·I NagaokaD Heumann
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anita W RijneveldTom van Der Poll
May 16, 2002·Chest·Teresa D Tetley
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·UNKNOWN ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories
Jun 5, 2003·The Journal of Clinical Investigation·Rembert KoczullaRobert Bals
Jan 15, 2004·The Journal of Clinical Investigation·Harold A Chapman
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas ElssnerMark D Wewers
Jul 28, 2004·Trends in Immunology·Anna Mondino, Francesco Blasi
Jun 21, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Renat ShaykhievRobert Bals
Oct 11, 2005·Biotechnology Letters·Kris De Smet, Roland Contreras
Nov 4, 2005·Proceedings of the American Thoracic Society·Robert P Schleimer
May 17, 2007·The European Respiratory Journal·D J PowrieJ A Wedzicha
May 18, 2007·American Journal of Respiratory and Critical Care Medicine·Klaus F RabeUNKNOWN Global Initiative for Chronic Obstructive Lung Disease

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Citations

Nov 2, 2011·Respiratory Medicine·Wolfram DoehnerMitja Lainscak
Feb 23, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Helen K ReddelDarryl A Knight
Feb 1, 2014·BMC Genomics·Santiyagu M Savarimuthu FrancisIan A Yang
Apr 26, 2014·The Clinical Respiratory Journal·Yao RongJin-Xiu Li
Jun 13, 2012·Respiratory Medicine·Gunnar EngströmKristina Forsman-Semb
Nov 18, 2017·Biological Chemistry·Lindsay R Stolzenburg, Ann Harris
Mar 15, 2018·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Gehan Hassan AboEl-Magd, Maaly Mohamed Mabrouk
Jun 25, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Robert J HallIan Sayers

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