[Urological manifestations of Down syndrome: significance and long-term complications -- our own patient cohort with an overview].

Der Urologe. Ausg. A
A K EbertW H Rösch

Abstract

In the literature urogenital anomalies are associated with Down syndrome. Anomalies of the external genitals, posterior urethral valves, and renal dys- or hypoplasia are reported. However, the incidence, etiology, and clinical course of neurogenic and functional bladder dysfunction in Down syndrome are unclear. We report on 23 boys and 1 girl with Down syndrome with a mean age of 79.4 months. Thirteen boys had uni- or bilateral cryptorchidism. Two had posterior urethral valves, two bladder exstrophy, and two hypospadias. Three children had neurogenic and eight non-neurogenic functional bladder dysfunction. Due to loss of renal function nephrectomy was necessary in three patients. Children with Down syndrome seem to often have associated neurogenic or functional bladder dysfunction, which can lead to upper urinary tract deterioration. Therefore, early and regular sonographic and urodynamic evaluation of the bladder function is mandatory.

References

Apr 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J C KupfermanR N Fine
Dec 6, 2001·Current Opinion in Urology·R J Nijman
Aug 15, 2002·Journal of Child Neurology·Matthias KieslichH Boehles
Feb 27, 2003·Journal of Neurochemistry·Ephrem Engidawork, Gert Lubec
Feb 10, 2004·The Journal of Urology·Erica Schalow MercerCharlotte A Massad
Apr 8, 2004·Journal of Neural Transmission. Supplementum·B L Shapiro
Nov 2, 2004·Pediatric Surgery International·Grace Chew, John M Hutson
Mar 24, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Serafín MálagaJoaquín Fernández-Toral
Dec 6, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Kuri SuzukiNobuyuki Hiruta
May 2, 2006·Journal of Physiology, Paris·Katherine SaudPablo Caviedes
Jun 10, 2006·European Journal of Medical Genetics·Rima DadaK Kucheria

❮ Previous
Next ❯

Citations

Jan 12, 2010·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Mohamed E Hassan, Abdulrahim Mustafawi
Nov 26, 2015·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Ashokan ArumugamNagarani Shanmugam
Apr 25, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Atsuko KitamuraHiroyuki Moriuchi
Oct 5, 2017·Revista da Associação Médica Brasileira·Adrianne Maria Berno de Rezende DuarteJosé Murillo de Bastos-Netto
May 19, 2012·The Journal of Urology·Zein M SammourMiguel Srougi
Jan 24, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Michael LudwigSimeon A Boyadjiev

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Braz J Urol : Official Journal of the Brazilian Society of Urology
Fabio C VicentiniMiguel Srougi
International Urology and Nephrology
J Kruk-JerominM Sosnowski
Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica
M Favre, T Enria
European Journal of Pediatrics
Anne Klusmann, Hans-Gerd Lenard
Emergency Medicine Clinics of North America
D A DreitleinJ Basler
© 2021 Meta ULC. All rights reserved