Uromodulin (Tamm-Horsfall protein) is a leukocyte adhesion molecule

Biochemical and Biophysical Research Communications
G TomaS Kumar

Abstract

Uromodulin (Tamm-Horsfall protein), the most abundant constituent of human urine, is synthesized exclusively in the kidney tubular epithelium and its amino acid sequence suggests a capacity for cell adhesion. We investigated adhesion between human uromodulin and neutrophils by allowing uromodulin, immobilized on microtiter plates, to interact with neutrophils. It was found that neutrophils attached to uromodulin in a saturable manner. The binding was inhibited by uromodulin in solution. It required metabolically active cells, was calcium sensitive and could be inhibited by arginine-glycine- aspartate-containing peptides in solution. These data suggest that uromodoulin can act as a specific ligand for neutrophils. This interaction is potentially important in leukocyte trafficking in the kidney and in the pathogenesis of interstitial nephritis.

Citations

Jan 13, 1999·Glycobiology·J J van RooijenJ F Vliegenthart
Jul 22, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thomas WimmerWalter H Hörl
Jan 27, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tarek M El-Achkar, Xue-Ru Wu
Nov 23, 2006·Journal of Biochemical and Biophysical Methods·Rakefet RosenfeldRuth Ben-Yakar Maya
Dec 10, 1999·The Urologic Clinics of North America·D E Neal
May 1, 1997·Kidney International·C L EdelsteinR W Schrier
Aug 12, 2014·Hypertension·Sandosh PadmanabhanAnna F Dominiczak
Apr 21, 1997·Carbohydrate Research·P B van SeeventerJ F Vliegenthart
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Feb 6, 2004·Best Practice & Research. Clinical Anaesthesiology·Norbert H Lameire, Raymond Vanholder

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