PMID: 9541475Apr 16, 1998Paper

Uroplakins and cytokeratins in the regenerating rat urothelium after sodium saccharin treatment

Histochemistry and Cell Biology
R RomihA Masera

Abstract

A sodium saccharin (NaSac) diet was used to induce cell damage and regeneration in the urothelium of the male rat urinary bladder. Foci of terminally differentiated superficial cell exfoliation were detected after 5 weeks and their number increased after 10 and 15 weeks of the diet. At the sites of superficial cell loss, regenerative simple hyperplasia developed. Within 5 weeks of NaSac removal, regeneration re-established normal differentiated urothelium. In order to follow urothelial differentiation during regeneration we studied the expression of uroplakins and cytokeratins by means of immunocytochemistry and immunohistochemistry, respectively. Normal urothelium was characterised by terminally differentiated superficial cells which expressed uroplakins in their luminal plasma membrane and cytokeratin 20 (CK20) in the cytoplasm. Basal and intermediate cells were CK20 negative and cytokeratin 17 (CK17) positive. In hyperplastic urothelium all cells synthesised CK17, but not CK20. Differentiation of the superficial layer was reflected in three successive cell types: cells with microvilli, cells with rounded microridges and those with a rigid-looking plasma membrane on the luminal surface. The cells with microvilli did not stain...Continue Reading

Citations

Sep 18, 2008·Histochemistry and Cell Biology·Peter VeranicKristijan Jezernik
Dec 1, 2011·Histochemistry and Cell Biology·Tanja VišnjarMateja Erdani Kreft
Apr 5, 2013·Histochemistry and Cell Biology·Andreja ErmanPeter Veranič
Apr 17, 2009·Cell and Tissue Research·Samo HudoklinRok Romih
Jun 4, 2010·Protoplasma·Mateja Erdani KreftRok Romih
Oct 21, 2006·Current Urology Reports·Emmanuel Graham, Toby C Chai
Sep 2, 2011·American Journal of Physiology. Renal Physiology·Weiqun Yu, Warren G Hill
Oct 20, 2007·The Journal of Clinical Investigation·Thomas GevaertBernd Nilius
Jun 2, 2010·Acta Histochemica Et Cytochemica·Hirohiko Iwatsuki, Masumi Suda
May 31, 2014·BioMed Research International·Gilho LeeDaša Zupančič
Mar 22, 2005·Cell and Tissue Research·Rok RomihKristijan Jezernik
Nov 22, 2008·BJU International·Christopher C RothBradley P Kropp
Jan 24, 2009·Annals of the New York Academy of Sciences·Mateja Erdani KreftRok Romih
Jun 29, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Siam OottamasathienJohn C Pope
Feb 10, 2007·Developmental Biology·Siam OottamasathienRobert J Matusik
Jun 21, 2016·Nature Communications·George PapafotiouApostolos Klinakis
Feb 28, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Rok RomihKristijan Jezernik
Oct 25, 2002·International Journal of Cancer. Journal International Du Cancer·Jean-François BissonFrançois Guillemin
Jun 17, 2011·Toxicologic Pathology·John A WislerSteven Vonderfecht
Jan 22, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Caihong WangIndira U Mysorekar
Mar 7, 2018·International Urology and Nephrology·C WasénD Giglio
Mar 24, 2017·American Journal of Physiology. Renal Physiology·F Aura KullmannGerard Apodaca
Jan 27, 2017·American Journal of Physiology. Renal Physiology·Zarine R Balsara, Xue Li
Feb 28, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Rok RomihKristijan Jezernik
Apr 22, 2009·Virchows Archiv : an International Journal of Pathology·Dasa ZupancicKristijan Jezernik
Jan 6, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S DesaiM B Amin
Aug 15, 2014·Experimental and Therapeutic Medicine·Jie DingJun Qi
May 21, 2020·International Journal of Molecular Sciences·Eva ErzarAndreja Erman
Oct 2, 2015·American Journal of Physiology. Renal Physiology·Nicolas MontalbettiMarcelo D Carattino
Mar 20, 2020·Physiological Reviews·Marianela G DalghiGerard Apodaca
Apr 17, 2004·European Journal of Cell Biology·Peter VeranicKristijan Jezernik

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