PMID: 5259767Jul 1, 1969Paper

Uroporphyrinogen 3 cosynthetase in human congenital erythropoietic porphyria

Proceedings of the National Academy of Sciences of the United States of America
G Romeo, E Y Levin

Abstract

Activity of the enzyme uroporphyrinogen III cosynthetase in hemolysates from five patients with congenital erythropoietic porphyria was much lower than the activity in control samples. The low cosynthetase activity in patients was not due to the presence of a free inhibitor or some competing enzymatic activity, because hemolysates from porphyric subjects did not interfere either with the cosynthetase activity of hemolysates from normal subjects or with cosynthetase prepared from hematopoietic mouse spleen. This partial deficiency of cosynthetase in congenital erythropoietic porphyria corresponds to that shown previously in the clinically similar erythropoietic porphyria of cattle and explains the overproduction of uroporphyrin I in the human disease.

References

Nov 1, 1968·Biochemistry·E Y Levin
Feb 1, 1954·A.M.A. Archives of Internal Medicine·R SCHMIDC J WATSON
Dec 20, 1963·Deutsche medizinische Wochenschrift·L HEILMEYERH P WETZEL
Jun 17, 1950·Nature·A NEUBERGERC H GRAY

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Citations

Jan 1, 1978·The International Journal of Biochemistry·A Gajdos, M Gajdos-Török
Jan 1, 1978·The International Journal of Biochemistry·M R MooreS Seubert
Jan 1, 1980·The International Journal of Biochemistry·S Kramer, J D Viljoen
Apr 29, 1998·Clinics in Dermatology·J T Hindmarsh
Jul 25, 2008·Biochemistry·Heidi L SchubertChristopher P Hill
Dec 3, 1999·The British Journal of Dermatology·A Herrera Saval, A Moruno Tirado
Jun 13, 2002·British Journal of Haematology·Robert J Desnick, Kenneth H Astrin
Jan 18, 1973·The New England Journal of Medicine·A W WolkoffI M Arias
Apr 12, 1973·The New England Journal of Medicine·L J Strand
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·C J WatsonZ J Petryka
May 2, 2002·Journal of Hematotherapy & Stem Cell Research·Nabil Saba, Thomas Flaig
Dec 1, 1977·British Journal of Haematology·S KramerJ D Viljoen
Nov 29, 1974·Annals of the New York Academy of Sciences·E Y Levin
Apr 15, 1975·Annals of the New York Academy of Sciences·E Y Levin
Dec 1, 1972·The Journal of Clinical Investigation·J P KushnerS Nacht
Jan 1, 1973·The Journal of Clinical Investigation·E Y Levin, V Flyger
Mar 1, 1993·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·L VerstraetenY Nordmann
Apr 1, 1995·Journal of Bioenergetics and Biomembranes·H de VerneuilF Moreau-Gaudry
Nov 17, 2009·Cellular and Molecular Life Sciences : CMLS·Maria J MarcaidaGuillermo Montoya
Feb 23, 1971·Biochimica Et Biophysica Acta·G Romeo, E Y Levin
Jun 18, 1974·Biochimica Et Biophysica Acta·R B Frydman, G Feinstein
Aug 1, 1983·Clinical Biochemistry·J T Hindmarsh
May 1, 1996·Journal of the American Academy of Dermatology·J L HuangM B Poh-Fitzpatrick
Apr 1, 1985·Clinics in Dermatology·M B Poh-Fitzpatrick
Apr 1, 1985·Clinics in Dermatology·N R Pimstone
Aug 1, 1983·European Journal of Clinical Investigation·D J ViljoenS Kramer
Sep 1, 1996·The Journal of Pediatrics·C ThomasS Blanche
Mar 13, 2016·British Journal of Haematology·Elena Di PierroFrancesca Granata
Jul 1, 1993·The British Journal of Dermatology·R J HiftR E Kirsch
Feb 22, 2012·Molecular Biology Reports·Meysam MoghbeliMohammad Reza Abbaszadegan

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