Uroprotective mechanism of quercetin against cyclophosphamide-induced urotoxicity: Effect on oxidative stress and inflammatory markers

Journal of Cellular Biochemistry
Iman O Sherif

Abstract

The urotoxicity is a common complication associated with patients receiving cyclophosphamide (CYP). This study was designed to investigate the uroprotective mechanism of quercetin (Quer) flavonoid against CYP induced urotoxicity via determination of oxidative stress markers as well as inflammatory mediators in bladder tissue. Forty male Wistar rats were divided into four groups; Normal group: received saline for 10 days. Quer control group: received quercetin 50 mg/kg/day for 10 days. CYP group: received saline for 10 days and injected with a single dose of 150 mg/kg CYP intraperitoneal (i.p) at day 8. The Quer + CYP group: received Quer 50 mg/kg/day for 10 days plus CYP 150 mg/kg i.p. injection at day 8. The CYP injection produced a significant elevation in bladder contents of malondialdehyde (MDA), and nitric oxide (NO), and bladder protein levels and expressions of tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) in addition to the upregulation of cyclooxygenase-2 (COX-2) bladder gene expression. Also, CYP injection showed a marked reduction in bladder levels of catalase, superoxide dismutase (SOD), and IL-10 when compared with normal group. Moreover, histopathological examination of the bladder showed degenerat...Continue Reading

References

May 1, 1978·Analytical Biochemistry·M Mihara, M Uchiyama
Jan 31, 1972·Biochemical and Biophysical Research Communications·M NishikimiK Yagi
Jan 1, 1984·Methods in Enzymology·H Aebi
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·V Y HuM A Vizzard
Feb 1, 2003·Trends in Pharmacological Sciences·Kotha Subbaramaiah, Andrew J Dannenberg
Apr 5, 2003·Toxicology Letters·László VirágCsaba Szabó
Feb 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Margaret M TarpeyMatthew B Grisham
Jan 1, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K K Wu
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Virginia Vila-del Sol, Manuel Fresno
Jul 20, 2007·Journal of Cancer Research and Clinical Oncology·Francisco Yuri Bulcao MacedoRonaldo Albuquerque Ribeiro
Feb 4, 2010·Acta Cirúrgica Brasileira·Anna Carolina Batista DantasAldo Cunha Medeiros
May 27, 2010·Indian Journal of Pharmaceutical Sciences·A Vidhya, M Indira
Jul 30, 2010·Pharmacognosy Magazine·Xi Chen
Nov 26, 2010·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Marina MilenkovićIvan Jančić
Jul 27, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Vinícios T BoeiraFernanda B Morrone
May 23, 2013·Journal of Biochemical and Molecular Toxicology·Osama M Abo-Salem
May 30, 2013·Indian Journal of Pharmacology·Amir Abbas FarshidSepideh Ranjbar
Apr 18, 2014·Indian Journal of Pharmacology·Ali A OzguvenAli Onag
Sep 25, 2014·International Urology and Nephrology·Ibrahim KelesMehmet Emin Buyukokuroglu
Jul 25, 2015·Journal of Biochemical and Molecular Toxicology·Ersin UysalSevket Ercan Tunc
Feb 26, 2016·The International Journal of Biochemistry & Cell Biology·Iman O SherifOsama M Sarhan
Apr 11, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hatice IskenderSinan Saral
May 30, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Emin ŞengülAli Çınar
Sep 1, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Štefan TóthPeter Kruzliak

❮ Previous
Next ❯

Citations

Nov 18, 2019·Biological Trace Element Research·Adnan AyhanciIlknur Kulcanay Sahin
Mar 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong XuYuan-Lu Cui
Mar 21, 2019·Drug and Chemical Toxicology·Amr A FouadManal I Abdelghany
Jun 3, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohamed Mohamed SolimanWafaa Abdou Mohamed
Jun 3, 2021·International Journal of Molecular Sciences·Andrzej WróbelPiotr Radziszewski
Aug 4, 2021·Journal of Complementary & Integrative Medicine·Licyanne Ingrid C LemosLucia Fatima C Pedrosa
Nov 4, 2021·BMC Complementary Medicine and Therapies·Quadri K AlabiDeborah Kajewole-Alabi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here