Urotensin II and biomarkers of endothelial activation and atherosclerosis in end-stage renal disease

American Journal of Hypertension
F MallamaciC Zoccali

Abstract

Urotensin II (UTN), a cyclic undecapeptide widely distributed in various organs and tissues, is found in high concentration in atheromatous lesions. Because UTN accumulates in patients with chronic renal failure, the association between plasma UTN and biomarkers of atherosclerosis and endothelial activation needs to be better understood. We tested by a robust statistical approach (Holm method) the association between plasma UTN and biomarkers of atherosclerosis and endothelial activation in a population of 191 patients undergoing chronic hemodialysis. Plasma UTN was significantly higher in patients with end-stage renal disease (median: 6.5 ng/mL) than in healthy subjects (median: 3.1 ng/mL) (P < .001), and in both patients and control subjects it was independent of age and sex. Interestingly, UTN was inversely related to fibrinogen (r = -0.50, P < .004), intracellular adhesion molecule-1 (r = -0.24, P < .004) and with NO synthesis inhibitor asymmetric dimethyl-arginine (r = -0.40, P < .004). These links were paralleled by direct correlations with albumin (r = 0.21, P < .006) and with transforming growth factor-beta1 (TGFbeta1) (r = 0.36, P < .004). Of note, on multiple regression analysis, these associations remained highly sig...Continue Reading

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Citations

Oct 26, 2007·American Journal of Nephrology·Johannes Jacobi, Philip S Tsao
Feb 14, 2008·Expert Opinion on Therapeutic Targets·Fernanda R C GiachiniR Clinton Webb
Oct 16, 2007·Peptides·Markus Tölle, Markus van der Giet
Dec 19, 2007·Hypertension·Carmine ZoccaliLorenzo Malatino
Feb 16, 2008·Current Opinion in Nephrology and Hypertension·Carmine ZoccaliFrancesca Mallamaci
Oct 3, 2009·Clinical Chemistry·Yen-Hsing ChenSuetonia C Palmer
Apr 28, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bryan RossAdel Giaid
Aug 13, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ozan BalakanCelaletdin Camci
Jun 15, 2007·Current Opinion in Nephrology and Hypertension

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