Abstract
Urotensin-II (U-II) is a vasoactive peptide with diffuse expression in human cardiomyocyte and vascular smooth muscle cells. Recent studies have reported increased plasma levels of U-II in patients with congestive heart failure. We sought to determine the plasma levels of U-II in patients with acute coronary syndromes (ACS), stable coronary artery disease (CAD) and healthy controls. We prospectively measured plasma U-II levels in 54 patients with ACS, 51 patients with stable coronary disease and 29 healthy volunteers. Monoclonal antibodies against U-II were generated and plasma U-II levels were determined by radioimmunoassay from extracted venous samples. ACS patients had significantly lower levels than patients with stable CAD and healthy controls (2.53+/-1.62 vs. 3.45+/-2.53 vs. 3.3+/-3.9 ng/ml, p=0.008, respectively). In both ACS and stable CAD patients, we found a negative relationship between plasma U-II levels and systemic arterial pressures. The correlation coefficients for systolic and mean arterial pressure were -0.272, p=0.006 and -0.209, p=0.04, respectively. Plasma U-II levels were significantly decreased in patients with acute coronary syndromes and related negatively to systemic arterial pressures. This finding su...Continue Reading
References
Nov 1, 1992·Journal of Molecular and Cellular Cardiology·F BrunnerL H Opie
Nov 1, 1994·British Heart Journal·I WieczorekK A Fox
Apr 1, 1994·Circulation·T OmlandK Dickstein
Aug 15, 1996·Circulation·C E ZauggP T Buser
Sep 28, 1999·Nature·R S AmesS A Douglas
Oct 4, 2000·British Journal of Pharmacology·J J MaguireA P Davenport
Jan 13, 2001·British Journal of Pharmacology·F D RussellD M O'Brien
Sep 21, 2001·Lancet·K TotsuneO Murakami
Jan 12, 2002·British Journal of Pharmacology·Felix Böhm, John Pernow
Jun 22, 2002·Lancet·Stephen A DouglasAdel Giaid
Sep 21, 2002·Lancet·A Mark RichardsTimothy G Yandle
Nov 26, 2002·Journal of Hepatology·Jörg HellerTilman Sauerbruch
Dec 4, 2002·Circulation·Leong L NgJoan E Davies
Jan 10, 2003·Clinical Science·Kazuhito TotsuneOsamu Murakami
Apr 12, 2003·Current Opinion in Pharmacology·Stephen A Douglas
Jun 7, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Fraser D RussellPeter Molenaar
Dec 20, 2003·Hybridoma and Hybridomics·Jui-Lan SuFrederick C Kull
Citations
Aug 8, 2007·Journal of Anesthesia·John McDonaldDavid G Lambert
Jan 29, 2011·Clinical Rheumatology·Yavuz PehlivanTaner Babacan
Dec 5, 2006·Current Hypertension Reports·Nicolas Bousette, Adel Giaid
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Halmurat UpurNicholas Moore
Aug 31, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takuya WatanabeTakashi Katagiri
Mar 20, 2014·Peptides·Hamood Al KindiAdel Schwertani
Oct 19, 2007·Kidney International·P RavaniC Zoccali
Nov 3, 2006·Kidney International·C Zoccali
Jul 31, 2010·Journal of Cardiac Failure·W H Wilson TangRichard W Troughton
Apr 14, 2009·Atherosclerosis·Mitsutoshi OguriYoshiji Yamada
Jul 9, 2008·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Rajbabu Pakala
Jul 6, 2007·Peptides·Kwok Leung OngBernard M Y Cheung
Jun 8, 2007·Peptides·Gregory S HarrisLaxmansa C Katwa
Jun 20, 2006·British Journal of Pharmacology·Yi-Chun ZhuPhilip Keith Moore
Jun 2, 2009·Bioorganic & Medicinal Chemistry·Fredrik LehmannKristina Luthman
Dec 19, 2007·Hypertension·Carmine ZoccaliLorenzo Malatino
Feb 16, 2008·Current Opinion in Nephrology and Hypertension·Carmine ZoccaliFrancesca Mallamaci
Apr 17, 2008·Cardiology in Review·Nirav DesaiWilliam H Frishman
Oct 3, 2009·Clinical Chemistry·Yen-Hsing ChenSuetonia C Palmer
Apr 28, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bryan RossAdel Giaid
Jun 27, 2021·Journal of Cardiovascular Pharmacology·Chun-Lin YinYan Yin