Urotensin-ⅡReceptor Antagonist SB-710411 Protects Rat Heart against Ischemia-Reperfusion Injury via RhoA/ROCK Pathway

PloS One
Sheng-Yong LuoZhi-Wu Chen

Abstract

SB-710411 is a rat selective urotensin-II (U-II) receptor antagonist, which can block U-II-induced contraction of the aorta and inhibit U-II-induced myocardial fibrosis in rats. However, the effect of SB-710411 on myocardial ischemia-reperfusion (I/R) injury is unclear. The present study was designed to investigate whether SB-710411 has a protective effect on myocardial I/R injury in rats and the possible mechanisms. Myocardial I/R injury was induced by occluding the left anterior descending coronary artery in adult male Sprague-Dawley rats. Hemodynamic parameters, electrocardiogram (ECG), infarct size, histological alteration, lactate dehydrogenase (LDH), creatine phosphokinase-MB (CK-MB), cardiac troponin I (cTnI), RhoA, and the protein expressions of U-II receptor (UTR), ROCK1 and ROCK2 were evaluated. Cardiac I/R injury significantly up-regulated the expressions of UTR, ROCK1 and ROCK2 proteins in rat myocardium. SB-710411 1.0 and 2.0 μg/kg significantly reduced cardiac I/R-induced the infarct size and histological damage in rat myocardium, markedly inhibited the changes of hemodynamic parameters and the increases of ST-segment in ECG, the serum LDH and CK-MB activities and cTnI level in rats subjected to myocardial I/R inj...Continue Reading

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Citations

May 10, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Kai XiaWei Wang
Jul 8, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Xinqi ChengZhiwu Chen
Mar 16, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Sheng-Yong LuoZhi-Wu Chen
May 18, 2021·Journal of Molecular Histology·Wei HuangAnying Li

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
protein assay
electrophoresis
transgenic

Software Mentioned

SPSS
ImageJ

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