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Urothelial Carcinoma Detection Based on Copy Number Profiles of Urinary Cell-Free DNA by Shallow Whole-Genome Sequencing

Clinical Chemistry

Dec 8, 2019

Guangzhe GeWeimin Ci

Abstract

Current noninvasive assays for urothelial carcinoma (UC) lack clinical sensitivity and specificity. Given the utility of plasma cell-free DNA (cfDNA) bio-markers, the development of urinary cfDNA biomarkers may improve the diagnostic sensitivity. We assessed copy number alterations (CNA...read more

Mentioned in this Paper

Ucb 30889
Local
Detection
Validation
Neoplasms
Urothelial Carcinoma
Plasma
Genome-Wide Association Study
Cell-Free DNA
Urine
9
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Urothelial Carcinoma Detection Based on Copy Number Profiles of Urinary Cell-Free DNA by Shallow Whole-Genome Sequencing

Clinical Chemistry

Dec 8, 2019

Guangzhe GeWeimin Ci

PMID: 31811000

DOI: 10.1373/clinchem.2019.309633

Abstract

Current noninvasive assays for urothelial carcinoma (UC) lack clinical sensitivity and specificity. Given the utility of plasma cell-free DNA (cfDNA) bio-markers, the development of urinary cfDNA biomarkers may improve the diagnostic sensitivity. We assessed copy number alterations (CNA...read more

Mentioned in this Paper

Ucb 30889
Local
Detection
Validation
Neoplasms
Urothelial Carcinoma
Plasma
Genome-Wide Association Study
Cell-Free DNA
Urine
9

Related Papers

Paper Details
References
  • References40
  • Citations
1234
  • References40
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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