Urothelial carcinoma of the bladder in patients on hemodialysis: clinical characteristics and oncological outcomes

The Journal of Urology
Ofer YossepowitchJack Baniel

Abstract

We characterized the clinical presentation and outcome of patients on hemodialysis diagnosed with urothelial carcinoma of the bladder. Patients treated for bladder cancer while undergoing maintenance hemodialysis were identified by querying the medical registry of a university affiliated hospital between 1999 and 2010. Clinical, pathological and treatment related data were retrieved and characterized. The study end points were recurrence-free, progression-free and overall survival. A total of 15 patients met study criteria. Median age at hemodialysis onset was 67 years (IQR 62, 74). Median dialysis duration before the bladder cancer diagnosis was 36 months (IQR 12, 60). Hematuria and bloody urethral discharge were the most common clinical manifestations. Tumors were generally large and multifocal. Of the patients 66% had invasive disease (T1 or greater) at presentation and 73% had high grade tumors. There were no adverse sequelae after transurethral resection or intravesical therapy. Two of the 4 patients treated with total urinary exenteration died soon after surgery and 1 had a grade IV complication. At a median followup of 18 months the estimated recurrence-free survival rate was 54% at 1 year, and 43% each at 2 and 3 years....Continue Reading

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Citations

Jul 30, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S-L LiuX-B Zu
Jan 14, 2016·International Urology and Nephrology·Yasuyuki SatoKazunari Tanabe
Sep 26, 2016·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F KleinclaussM O Timsit
May 18, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Jeffrey LawAlp Sener
Sep 23, 2018·Annals of Surgical Oncology·Yun-Ching Huang
Apr 3, 2020·Current Opinion in Urology·Benjamin PradereReza Sari Motlagh

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