Urothelial damage and tumor initiation by urinary metabolites of sodium o-phenylphenate in the urinary bladder of female rats

Japanese Journal of Cancer Research : Gann
R HasegawaY Hayashi

Abstract

Intravesical instillation of 2-phenyl-1,4-benzoquinone (PBQ), a metabolite of sodium o-phenylphenate (Na-OPP), at a concentration of 0.1% in saline caused acute epithelial injury, prolonged inflammation and epithelial hyperplasia in female F344 rats. Ten such instillations of PBQ within 5 weeks resulted in the development of preneoplastic lesions of the urinary bladder epithelium when followed by 5% sodium saccharin feeding for 31 weeks. Since neither urothelial damage nor tumor-initiating activity was observed with either Na-OPP itself or another metabolite, phenylhydroquinone, PBQ may play an essential role in Na-OPP urinary bladder carcinogenesis.

References

May 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T FujiiK Hiraga
Mar 1, 1986·Cancer Letters·R Hasegawa, S M Cohen
Apr 1, 1985·Mutation Research·H SuzukiK Hiraga
Oct 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A HagiwaraN Ito
Nov 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K Hiraga, T Fujii
Jun 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T NakaoK Hiraga
Jan 1, 1983·Chemico-biological Interactions·R H ReitzP G Watanabe

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Citations

Feb 27, 2016·Environmental and Molecular Mutagenesis·S BalakrishnanD A Eastmond
Apr 20, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Balakrishnan, D A Eastmond
Dec 19, 2002·Critical Reviews in Toxicology·E M BomhardM Richter

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