journal cover

Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity

Nature Communications

Sep 27, 2019

Catarina P. SantosFrancisco X. Real

Get paper from

Abstract

Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained uninterruptedly for >1 year. Organoid growth is dependent on EGF and Wnt activator...read more

Mentioned in this Paper

Biological Markers
Cell Differentiation Process
Gene Expression
Ligands
Laboratory mice
Organoids
Epidermal Growth Factor Receptor
Natural Regeneration
Ribosomes
Stem Cells
9
7
1
10
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

General Biology Journal eTOCs

Discover the latest general biology research in this collection of the top biology journals.

Organ Regeneration

Regeneration in humans is the regrowth of tissues or organs in response to injury or damage. Discover the latest research on organ neuroregeneration here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Neuroregeneration

Neuroregeneration is the growth or repair of neural cells and tissues following damage or injury. Discover the latest research on neuroregeneration here.

Transglutaminase 2 & Adipogenesis

Transglutaminase 2 is a multifunctional and protein crosslinking enzyme present in the white adipose tissue. Recent studies have implicated this protein as a novel negative regulator of adipogenesis. Here is the latest research.

Organoids

Organoids are three-dimensional structures derived from adult or embryonic stem cells, tissues, or tumors, that enable the mimicry of in vivo architecture in tissue culture. Here is the latest research on organoids.

© 2019 Meta ULC. All rights reserved

Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity

Nature Communications

Sep 27, 2019

Catarina P. SantosFrancisco X. Real

PMID: 31562298

DOI: 10.1038/s41467-019-12307-1

Abstract

Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained uninterruptedly for >1 year. Organoid growth is dependent on EGF and Wnt activator...read more

Mentioned in this Paper

Biological Markers
Cell Differentiation Process
Gene Expression
Ligands
Laboratory mice
9
7
1
10

Related Papers

Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Get paper from

/papers/urothelial-organoids-originating-from-cd49fhigh/31562298