PMID: 26350747Sep 10, 2015Paper

Ursodeoxycholic acid decreases age-related adiposity and inflammation in mice

BMB Reports
Ah-Reum OhJi-Young Cha

Abstract

Ursodeoxycholic acid (UDCA), a natural, hydrophilic nontoxic bile acid, is clinically effective for treating cholestatic and chronic liver diseases. We investigated the chronic effects of UDCA on age-related lipid homeostasis and underlying molecular mechanisms. Twenty-week-old C57BL/6 male and female mice were fed a diet with or without 0.3% UDCA supplementation for 25 weeks. UDCA significantly reduced weight gain, adiposity, hepatic triglyceride, and hepatic cholesterol without incidental hepatic injury. UDCA-mediated hepatic triglyceride reduction was associated with downregulated hepatic expression of peroxisome proliferator-activated receptor-γ, and of other genes involved in lipogenesis (Chrebp, Acaca, Fasn, Scd1, and Me1) and fatty acid uptake (Ldlr, Cd36). The inflammatory cytokines Tnfa, Ccl2, and Il6 were significantly decreased in liver and/or white adipose tissues of UDCA-fed mice. These data suggest that UDCA exerts beneficial effects on age-related metabolic disorders by lowering the hepatic lipid accumulation, while concurrently reducing hepatocyte and adipocyte susceptibility to inflammatory stimuli. [BMB Reports 2016; 49(2): 105-110].

References

Oct 22, 1998·The New England Journal of Medicine·M TraunerJ L Boyer
Aug 10, 2001·Journal of Hepatology·K N LazaridisK D Lindor
Sep 19, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·E RodaG Mazzella
Dec 1, 2004·Aging Cell·Daniel Amador-NoguezGretchen Darlington
Jan 28, 2005·European Journal of Gastroenterology & Hepatology·Stefano Bellentani
Jul 11, 2006·The Journal of Clinical Investigation·Steven E ShoelsonAllison B Goldfine
May 25, 2007·Aging Cell·Daniel Amador-NoguezGretchen Darlington
Aug 12, 2008·Ageing Research Reviews·Hae Young ChungChristiaan Leeuwenburgh
Apr 7, 2009·Journal of Lipid Research·John Y L Chiang
May 4, 2011·NMR in Biomedicine·Patrícia M NunesRui A Carvalho
Dec 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anita PathilWolfgang Stremmel
Apr 26, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Biao NieAndreas Stahl
Sep 21, 2013·Molecular Metabolism·Risheng Ye, Philipp E Scherer
Sep 23, 2014·International Journal of Molecular Sciences·Anthony Arlia-CiommoVladimir I Titorenko
Jun 27, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Jenny C LinkKaren Reue

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Citations

Jan 19, 2018·Experimental Animals·Jae-Il RohHan-Woong Lee
Dec 19, 2018·The Proceedings of the Nutrition Society·F FavaK M Tuohy
May 10, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shahsanam GheibiLeila Zarei

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