Urtica dioica modulates hippocampal insulin signaling and recognition memory deficit in streptozotocin induced diabetic mice

Metabolic Brain Disease
Sita Sharan PatelMalairaman Udayabanu

Abstract

Diabetes mellitus has been associated with functional abnormalities in the hippocampus and performance of cognitive function. Urtica dioica (UD) has been used in the treatment of diabetes. In our previous report we observed that UD extract attenuate diabetes mediated associative and spatial memory dysfunction. The present study aimed to evaluate the effect of UD extract on mouse model of diabetes-induced recognition memory deficit and explore the possible mechanism behind it. Streptozotocin (STZ) (50 mg/kg, i.p. consecutively for 5 days) was used to induce diabetes followed by UD extract (50 mg/kg, oral) or rosiglitazone (ROSI) (5 mg/kg, oral) administration for 8 weeks. STZ induced diabetic mice showed significant decrease in hippocampal insulin signaling and translocation of glucose transporter type 4 (GLUT4) to neuronal membrane resulting in cognitive dysfunction and hypolocomotion. UD treatment effectively improved hippocampal insulin signaling, glucose tolerance and recognition memory performance in diabetic mice, which was comparable to ROSI. Further, diabetes mediated oxidative stress and inflammation was reversed by chronic UD or ROSI administration. UD leaves extract acts via insulin signaling pathway and might prove t...Continue Reading

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Citations

Apr 29, 2018·Metabolic Brain Disease·Sita Sharan PatelMalairaman Udayabanu
Dec 29, 2016·Reviews in the Neurosciences·Sita Sharan Patel, Malairaman Udayabanu
Aug 14, 2020·Pflügers Archiv : European journal of physiology·Hermann Koepsell
May 28, 2019·International Journal of Molecular Sciences·Carmen Infante-Garcia, Monica Garcia-Alloza
Dec 15, 2020·Physiology & Behavior·Zeinab MomeniVerónica A Campanucci
Apr 14, 2021·The International Journal of Neuroscience·Mohammad Amin RajizadehFouzieh Salimi
Apr 12, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Masoud RahmatiFarzaneh Chehelcheraghi
Aug 3, 2021·The Journal of Veterinary Medical Science·Krittika SrisuksaiWirasak Fungfuang
Jul 18, 2020·CNS & Neurological Disorders Drug Targets·Roma GhaiGarima Kapoor

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