US Time-Harmonic Elastography: Detection of Liver Fibrosis in Adolescents with Extreme Obesity with Nonalcoholic Fatty Liver Disease

Radiology
Christian A HudertIngolf Sack

Abstract

Purpose To measure in vivo liver stiffness by using US time-harmonic elastography in a cohort of pediatric patients who were overweight to extremely obese with nonalcoholic fatty liver disease (NAFLD) and to evaluate the diagnostic value of time-harmonic elastography for differentiating stages of fibrosis associated with progressive disease. Materials and Methods In this prospective study, 67 consecutive adolescents (age range, 10-17 years; mean body mass index, 34.7 kg/m2; range, 21.4-50.4 kg/m2) with biopsy-proven NAFLD were enrolled. Liver stiffness was measured by using time-harmonic elastography based on externally induced continuous vibrations of 30 Hz to 60 Hz frequency and real-time B-mode-guided wave profile analysis covering tissue depths of up to 14 cm. The diagnostic accuracy of time-harmonic elastography in staging liver fibrosis was assessed with area under the receiver operating characteristic curve (AUC) analysis. Liver stiffness cutoffs for the differentiation of fibrosis stages were identified based on the highest Youden index. Results Time-harmonic elastography was feasible in all patients (0% failure rate), including 70% (n = 47) of individuals with extreme obesity (body mass index above the 99.5th percentil...Continue Reading

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Citations

Nov 18, 2018·Investigative Radiology·Christian A HudertJing Guo
Mar 19, 2019·Ultrasonography·Richard Gary Barr
Jun 7, 2019·Physics in Medicine and Biology·Juvenal OrmacheaRichard G Barr
May 16, 2018·Radiology·Richard G Barr
Dec 10, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Armando ManducaBernard E Van Beers
Feb 4, 2021·Medicine·Cristina Oana MărgineanMaria Oana Săsăran
Sep 16, 2020·Current Problems in Pediatric and Adolescent Health Care·Krista McNeice, Kelly Sandberg
Apr 25, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Laura G DraijerBart G P Koot
Aug 13, 2021·Investigative Radiology·Bernhard KreftKaspar-Josche Streitberger

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