Usability of prostaglandin monotherapy eye droppers

The British Journal of Ophthalmology
Tom Drew, James S Wolffsohn

Abstract

To determine the force needed to extract a drop from a range of current prostaglandin monotherapy eye droppers and how this related to the comfortable and maximum pressure subjects could exert. The comfortable and maximum pressure subjects could apply to an eye dropper constructed around a set of cantilevered pressure sensors and mounted above their eye was assessed in 102 subjects (mean 51.2±18.7 years), repeated three times. A load cell amplifier, mounted on a stepper motor controlled linear slide, was constructed and calibrated to test the force required to extract the first three drops from 13 multidose or unidose latanoprost medication eye droppers. The pressure that could be exerted on a dropper comfortably (25.9±17.7 Newtons, range 1.2-87.4) could be exceeded with effort (to 64.8±27.1 Newtons, range 19.9-157.8; F=19.045, p<0.001), and did not differ between repeats (F=0.609, p=0.545). Comfortable and maximum pressures exerted were correlated (r=0.618, p<0.001), neither were influenced strongly by age (r=0.138, p=0.168; r=-0.118, p=0237, respectively), but were lower in women than in men (F=12.757, p=0.001). The force required to expel a drop differed between dropper designs (F=22.528, p<0.001), ranging from 6.4 Newtons t...Continue Reading

References

Nov 24, 2004·The American Journal of Geriatric Pharmacotherapy·Rajesh BalkrishnanRoger T Anderson
May 21, 2010·BMC Musculoskeletal Disorders·Felix AngstJörg Goldhahn
Dec 16, 2011·Journal of Advanced Pharmaceutical Technology & Research·Shiva KumarDivakar Goli
Sep 7, 2013·Current Medical Research and Opinion·Gail F SchwartzJulia M Williams

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