Usage of Multiparameter Flow Cytometry to Study Microglia and Macrophage Heterogeneity in the Central Nervous System During Neuroinflammation and Neurodegeneration

Methods in Molecular Biology
Marina DukhinovaEugene D Ponomarev

Abstract

The resident macrophages of the central nervous system (CNS), also known as microglia, and blood-derived macrophages play an important role in the functional activity of the normal CNS, as well as in the development of neuroinflammation during various neurodegenerative disorders. Microglia and macrophages represent heterogeneous populations, which can modulate CNS environment and have different effects on neuronal regeneration. In this chapter, the main features of microglial and macrophage subsets and current methods for investigation of their heterogeneity will be discussed.

Citations

Oct 28, 2018·Journal of Neuroscience Research·Tatyana VeremeykoEugene D Ponomarev
Jun 24, 2020·Journal of Leukocyte Biology·Idy H T HoXiaodong Liu
Sep 7, 2018·Frontiers in Cellular Neuroscience·Md Ezazul HaqueDong-Kug Choi
May 25, 2021·Expert Opinion on Therapeutic Targets·M Collins ScottCharles S Cox

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